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The aim of this chapter is to present science education in ways that are meaningful and reflective of the interests of learners, their contexts and local needs. While there is emphasis on finding means to meeting the needs of the job market, there is a gap in identifying what learners need to know to compete in the global market and become proactive citizens. The chapter argues that a reform in education is required to address the 2030 sustainable development goals (SDGs) and types of jobs that are locally and globally related to addressing major local and global challenges. The chapter addresses this gap by expanding the current reference to STEM and STEAM education as an interdisciplinary perspective to a transdisciplinary one that includes the field of education for sustainable development (ESD). In doing so, the chapter highlights major global trends through the 2030 SDGs and major advancements in technology and how these can be integrated into a transdisciplinary STE2AM (double E) model. The focus of inquiry of this chapter, therefore, is to investigate a possible transdisciplinary model through a local lens in a country such as Egypt within a framework that meets local and global challenges and addresses the fourth industrial revolution.