This article considers major events that defined Botswana’s domestic politics, foreign policy and socioeconomic developments in 2021. The article in particular assesses how domestic politics was dominated by Covid-19 as its impact continued to paralyse the country’s socioeconomic development trajectory. Besides Covid-19, the actions of the Directorate of Intelligence and Security Services (DISS), corruption and money laundering, and the conflict between President Mokgweetsi Masisi and former president Ian Khama continued to be public issues, and impacted on the country’s governance. Ian Khama left the country citing maltreatment. An active foreign policy was upheld, and economic recovery was projected.