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Purity – be it of metals or medicines – was a central concern for early modern alchemists, and the purification of substances was a primary goal of alchemical processes. From distillation to calcination, the application of heat was often the key to transforming the substances at hand. To this end, fire was ubiquitous in early modern workshops. Yet fire was not the only source of heat (dung, for instance, could be used as a source of consistent, low-grade warmth) and it was often mediated (perhaps through water, in a bain marie). This paper examines the interplay between techniques of purification, especially those relying on heat, and broader ideas about the role of fire as a purifying agent, in the work of the seventeenth-century chymists Nicaise Le Febvre and Michael Sendivogius.