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In the Timaeus, Plato explains how the four elements are not the most elementary building blocks of sensible bodies. Fire, earth, water, and air are in fact three-dimensional solids composed of even more elementary triangles. This geometrical infrastructure accounts for a physical superstructure: inter-elemental transformations and sensible properties are explained by means of underlying mathematical configurations. Of course, the central question is how the relation between both levels of reality should be understood. Does Plato here defend a geometrical atomism – as some claim – or is his geometrical account merely a hypothetical exercise in saving the phenomena? This chapter examines how Renaissance readers of the Timaeus, such as Bessarion, Ficino, Fox-Morcillo, Beni, and Mazzoni, tried to answer these questions. It aims to show how the atomist interpretation was either downplayed as a hypothetical construct or defended on the authority of Neoplatonic philosophers such as Proclus and Simplicius.