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Vitamin E is the most important fat-soluble antioxidant especially applied in the animal nutrition. Due to its anti-inflammatory effects on the skin it is contained in many cosmetic products. In fact, if topically applied, vitamin E deactives unstable free radicals providing one of its electrons to the electron deficient free radical making it more stable. As a result, it protects the skin from deleterious effects due to its exposure to exogenous toxic agents such as pollulants, chemicals and sun rays, preventing the propagation of free-radicals. Although, mainly acting as an antioxidant, vitamin E can also exert a pro-oxidant activity. Vitamin E also regulates the functions of vitamin A in the body. This is fundamental because vitamin A itself is a dominant vitamin for skin care.