Chapter 10: Looking ahead: from the past to the future
In: Selenium in pig nutrition and healthDepartment of Hygiene and Poultry Sciences, Moscow State Academy of Veterinary Medicine and Biotechnology Named After K.I. Skryabin, 109472 Moscow, Russia.
Department of Microbiology and Biochemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria.
Department of Animal Nutrition, Faculty of Agricultural and Environmental Sciences, Szent Istvan University, 2103 Gödöllo, Hungary.
Saint-Petersburg State Academy of Veterinary Medicine, 196084 St. Petersburg, Russia.
Sumy National Agrarian University, 40000 Sumy, Ukraine.
Odessa National Academy of Food Technologies, 65039 Odessa, Ukraine.
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Our analysis of the literature reinforces the importance of Se in pig nutrition and health. In fact, from 25 known porcine selenoproteins more than half are involved in antioxidant defences and redox homeostasis maintenance. An important consideration of optimal Se nutrition is related to maintenance of redox homeostasis in the gut under various stress condition and effects of Se nutrition/status on Nrf2 and NF-κB expressions as well as anti-inflammatory properties of Se deserves more attention and additional research. Furthermore, several selenoproteins, including thioredoxin reductase and glutathione peroxidases are regulated at the vitagene level and their involvement in stress adaptation is an important topic of current research. In particular within precise nutrition concept there is a move from preventing Se deficiencies to meeting Se requirement and organic Se sources are shown to be an effective tool to achieve this goal. It seems likely that OH-SeMet is the most effective organic Se source for farm animals and poultry to date showing advantages in comparison to sodium selenite, Se-Yeast or pure SeMet/Zn-SeMet and it is just the matter of time before sodium selenite would be replaced by organic Se sources in commercial pig nutrition.