We participate in a metalogue to generate and expand several critical issues in science education. The issues concern science teacher education, science curriculum and its relationships to sociopolitical issues and connections to everyday life, and the role of the Institutional Review Board (IRB) in design and conduct of research in science education. Each of these central areas of science education is complex, and we identify and elaborate on our experiences as science educators to probe deeper into an expanding vortex of possibilities. Scientism and crypto-positivism emerge as pervasive referents for practices that maintain the status quo. Whereas our metalogue describes new pathways to consider in a quest for a bold new, relevant and sustainable science education, our purpose is to prepare readers for what is to follow in a book with 16 chapters authored by 31 scholars from 11 countries.