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In the awaking of the second millennium the world finds itself facing a series of globally interconnected and locally specific challenges: climate change, the quality and security of food, water and air pollution, political instability, refugee crisis, poverty, migration, racisms, sexisms, gender bias, and various other forms of sociopolitical and economic inequalities and oppressions. These challenges create new needs and raise expectations for science education, especially in addressing goals related to diversity, equity, and social change. In this chapter, we define theoretical constructs that feature centrally in efforts to address these goals in science education. Following on that, we offer as examples, brief descriptions of current research projects that we are engaged in, which are framed within these constructs and address goals and issues related to global challenges.