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The global community is engaged in educational reform to improve opportunities for young people in higher education and scientific research. The responsibility of science teacher educators extends to the preparation of world-class faculty in STEM disciplines at institutions of higher education (IHE). This chapter describes a highly intensive and innovative international dual-degree program designed to prepare world-class professors in STEM fields for colleges and universities. With about 150 million future students, some reports indicate that 50,000+ new colleges and universities are being formed in India (Choudaha, 2011). These new institutions of higher education need highly-qualified STEM faculty to train the next generation of leaders in STEM fields. A collaboration funded by the US-India Education Foundation (USIEF) between The Ohio State University (OSU) and the Aligarh Muslim University (AMU) was established with the primary goal of exploring pathways to prepare the next generation of world-class STEM faculty for universities in India. Theoretical frameworks and logistical challenges are described.