This article sketches a research agenda for the development of a Christianly inspired perspective in International Relations. It is argued that a practice-approach offers fruitful starting points for such an attempt. This approach shares three fundamental insights with the Christian philosophical approach known as Reformational philosophy, namely that science is just one mode of relating to the world, that human action and human freedom should be taken seriously, and that reality is intrinsically meaningful. In turn, Reformational philosophy can deepen existing practice-approaches on four points. In the first place, it addresses the fundamental notion that all human beings have an (Archimedean) point of trust. Secondly, it includes the notion that reality is made up of many dimensions. Thirdly, it takes seriously dominant cultural ideas or so-called ground motives. Finally, a Reformational approach is sensitive to vicissitudinary processes which may open up or close down certain positive developments in history.