Macrophage migration inhibitory factor modulates formalin induced behaviors in rats
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Cytokine proteins are involved in different signaling pathways throughout the central nervous system. To study the efficacy of an inflammatory cytokine, the macrophage migration inhibitory factor (MIF), which acts via several receptor molecules including the receptor CXCR2, male rats’ behaviors were determined after intracerebroventricular (ICV) administration of MIF. There were three treatments: One group received only the cytokine, a second group received MIF and an CXCR2 antagonist (SB265610), and a third, control group received only the carrier medium saline. All rats were subjected to a subcutaneous injection of formalin in the hind paw after the ICV administration. Pain behaviors induced after formalin injection showed increased values in the MIF group of licking in the first phase and increased values of flexing, licking and paw-jerk in the second phase. On the contrary, spontaneous behaviors induced by formalin injection changed alternatively between the two groups compared with saline. These results suggest a possible effect of cytokine MIF on central nervous processes implicated in pain modulation mediated by the receptor CXCR2.
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Macrophage migration inhibitory factor modulates formalin induced behaviors in rats
In: Animal BiologySearch for other papers by Alexandru F. Deftu in
Current site
Google Scholar
PubMed
Search for other papers by Paolo Fiorenzani in
Current site
Google Scholar
PubMed
Search for other papers by Ilaria Ceccarelli in
Current site
Google Scholar
PubMed
Search for other papers by Jessica Pinassi in
Current site
Google Scholar
PubMed
Search for other papers by Martina Gambaretto in
Current site
Google Scholar
PubMed
Search for other papers by Violeta Ristoiu in
Current site
Google Scholar
PubMed
Search for other papers by Luana R. Paulesu in
Current site
Google Scholar
PubMed
Search for other papers by Anna-Maria Aloisi in
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PubMed
Cytokine proteins are involved in different signaling pathways throughout the central nervous system. To study the efficacy of an inflammatory cytokine, the macrophage migration inhibitory factor (MIF), which acts via several receptor molecules including the receptor CXCR2, male rats’ behaviors were determined after intracerebroventricular (ICV) administration of MIF. There were three treatments: One group received only the cytokine, a second group received MIF and an CXCR2 antagonist (SB265610), and a third, control group received only the carrier medium saline. All rats were subjected to a subcutaneous injection of formalin in the hind paw after the ICV administration. Pain behaviors induced after formalin injection showed increased values in the MIF group of licking in the first phase and increased values of flexing, licking and paw-jerk in the second phase. On the contrary, spontaneous behaviors induced by formalin injection changed alternatively between the two groups compared with saline. These results suggest a possible effect of cytokine MIF on central nervous processes implicated in pain modulation mediated by the receptor CXCR2.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 531 | 58 | 6 |
| Full Text Views | 216 | 1 | 0 |
| PDF Views & Downloads | 23 | 1 | 0 |
