Rasauṣadhi, medicinal preparations made of mercury, form an important group of ayurvedic rasaśāstra medicines. Their manufacture, however, is decreasing due to the lack of reliable preparation for its safe and effective use. Rasasindūra is one such mercury-based compound that requires skill and experience to prepare. This practice report describes an event where this product was prepared in the academic setting of Smt. K. G. Mittal Punarvasu Ayurvedic College, Mumbai, in the winter of 1986–7, emphasising the specific skills that are required to make a reliable product, and thus providing a preliminary model for further studies of traditional drug processing techniques.