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The influence of probiotic Enterococcus faecium strain L5 on the microbiota and cytokines expression in rats with dysbiosis induced by antibiotics

In: Beneficial Microbes
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E. Tarasova Institute of Experimental Medicine, Ak. Pavlova st. 12, 197376 St. Petersburg, Russia

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E. Yermolenko Institute of Experimental Medicine, Ak. Pavlova st. 12, 197376 St. Petersburg, Russia

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V. Donets Medical Academy, Postgraduate School, Kirochnaya st. 41, 193015 St. Petersburg, Russia

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Z. Sundukova Medical Academy, Postgraduate School, Kirochnaya st. 41, 193015 St. Petersburg, Russia

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A. Bochkareva Institute of Experimental Medicine, Ak. Pavlova st. 12, 197376 St. Petersburg, Russia

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I. Borsсhev Institute of Physiology, Tuchkova emb. 6, 199164 St. Petersburg, Russia

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M. Suvorova Institute of Experimental Medicine, Ak. Pavlova st. 12, 197376 St. Petersburg, Russia

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I. Ilyasov Institute of Experimental Medicine, Ak. Pavlova st. 12, 197376 St. Petersburg, Russia

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V. Simanenkov Medical Academy, Postgraduate School, Kirochnaya st. 41, 193015 St. Petersburg, Russia

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A. Suvorov Institute of Experimental Medicine, Ak. Pavlova st. 12, 197376 St. Petersburg, Russia

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The animal model of intestinal dysbiosis induced by antibiotics was created. Dysbiotic condition was confirmed by the changes in titre of the indigenous microbiota (excessive growth of opportunistic microorganisms and reduced number of lactobacilli, bifidobacteria and enterococci) and the appearance of dyspeptic symptoms. Consumption of the fermented milk product with probiotic strain Enterococcus faecium L5 led to the rapid disappearance of dysbiosis symptoms, normalisation of the microbiota, increase in expression of IL-10 and decrease in IL-8 expression.

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