Save

Microencapsulated feruloyl esterase-producing lactobacilli ameliorate lipid profile and glycaemia in high fat diet-induced obese mice

In: Beneficial Microbes
Authors:
M. Russo Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucumán, Tucumán, Argentina.

Search for other papers by M. Russo in
Current site
Google Scholar
PubMed
Close
,
A. Marquez Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucumán, Tucumán, Argentina.

Search for other papers by A. Marquez in
Current site
Google Scholar
PubMed
Close
,
M.C. Abeijón-Mukdsi Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucumán, Tucumán, Argentina.

Search for other papers by M.C. Abeijón-Mukdsi in
Current site
Google Scholar
PubMed
Close
,
A. Santacruz Departamento de Biotecnología, Instituto Tecnológico y de Estudios Superiores de Monterrey, Av. Eugenio Garza Sada 2501 Sur, Tecnológico, 64849 Monterrey, México.

Search for other papers by A. Santacruz in
Current site
Google Scholar
PubMed
Close
,
A. López-Malo Departamento de Ingeniería Química, Alimentos y Ambiental, Universidad de las Américas Puebla, Hacienda Santa Catarina Mártir s/n. 72810, Cholula, Puebla, México.

Search for other papers by A. López-Malo in
Current site
Google Scholar
PubMed
Close
,
P. Gauffin-Cano Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucumán, Tucumán, Argentina.

Search for other papers by P. Gauffin-Cano in
Current site
Google Scholar
PubMed
Close
, and
R. Medina Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucumán, Tucumán, Argentina.
Universidad Nacional de Tucumán, Ayacucho 491, T4000INH, San Miguel de Tucumán, Tucumán, Argentina.

Search for other papers by R. Medina in
Current site
Google Scholar
PubMed
Close
Download Citation Get Permissions

Access options

Get access to the full article by using one of the access options below.

Institutional Login

Log in with Open Athens, Shibboleth, or your institutional credentials

Login via Institution

Purchase

Buy instant access (PDF download and unlimited online access):

The effect of oral administration of spray-dried microcapsules of feruloyl esterase (FE) producing Lactobacillus fermentum CRL1446 (Lf) and Lactobacillus johnsonii CRL1231 (Lj) on high fat diet-induced obese mice was investigated to evaluate whether these strains could be used as a biotherapeutic for obesity. Swiss albino mice were divided into a normal diet fed group receiving empty microcapsules (control), a high fat diet plus empty microcapsules (HFD group), HFD plus microcapsules with Lf (HFD-Lf group) and HDF plus microcapsules with Lj (HFD-Lj group). Microcapsules containing Lf or Lj at a dose of ~107 cells/day/mouse were given orally for 7 weeks. Body weight gain, adiposity index, plasma leptin, lipid profiles, glycaemia, insulinemia, oral glucose tolerance, intestinal FE, glutathione peroxidase and glutathione reductase (GR) activities were determined. Administration of lactobacilli (HFD-Lf and HFD-Lj groups) improved metabolic parameters (triglyceride, total cholesterol, low-density lipoprotein cholesterol levels) and cardiovascular risk indicators (37-46% decrease of atherogenic index), and reduced body weight gain (29-38%), adiposity index (42-62%), plasma leptin levels, liver weight and fat deposition in liver. Intestinal FE activities significantly increased in HFD-Lf (62%) and HFD-Lj group (48%), thus improving hepatic GR activity (42% increment) compared to HFD group. Moreover, L. johnsonii increased HDL-cholesterol and L. fermentum reduced blood glucose to levels similar to the control. These FE-producing lactobacilli have the potential to improve biomarkers involved in obesity by increasing intestinal FE activity.

Content Metrics

All Time Past Year Past 30 Days
Abstract Views 19 19 8
Full Text Views 5 5 2
PDF Views & Downloads 2 2 1