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Postbiotics: facts and open questions. A position paper on the need for a consensus definition

In: Beneficial Microbes
Authors:
M.C. Collado Institute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Av. Agustin Escardino 7, 46980 Valencia, Spain.
Functional Foods Forum, Faculty of Medicine, University of Turku, Turun Yliopisto, Turku 20014, Finland.

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G. Vinderola Instituto de Lactología Industrial (INLAIN, UNL-CONICET), Facultad de Ingeniería Química, Universidad Nacional del Litoral, Santiago del Estero 2829, Santa Fe 3000, Argentina.

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S. Salminen Functional Foods Forum, Faculty of Medicine, University of Turku, Turun Yliopisto, Turku 20014, Finland.

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The past definitions of probiotics and prebiotics have been reviewed and updated recently. According to these concepts, probiotics comprise live microorganisms that confer a health benefit on the host when administered in adequate amounts, whereas a prebiotic is a substrate that is selectively utilised by host microorganisms, conferring a health benefit. The words probiotics and prebiotics can be found on labels of many foods and supplements. Consumers have a growing awareness of these terms’ meanings, and many countries are increasingly using them for regulation purposes. At the same time, there is increasing evidence on the health effects of non-viable microorganisms and the metabolites that they can produce by fermentation or by their action on food components. Different terms have been used in the literature to refer to these bioactive compounds, which do not fall under the known categories of probiotics, prebiotics or synbiotics. The tentative term postbiotics has been the most used one so far. However, no definition of the term has gained international consensus to date. This work aims to provide information on the facts and the open questions about the so-called postbiotics.

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