Probiotics/prebiotics/synbiotics and human neuropsychiatric outcomes: an umbrella review
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Abstract
The neuropsychiatric effects of probiotics, prebiotics, and synbiotics have been gaining attention since the rise of microbial-gut-brain axis research. Nevertheless, some of the findings are inconsistent, and few studies have analysed the similarities and differences in the neuropsychiatric effects of the three comprehensively. To reveal the respective neuropsychiatric effects of probiotics, prebiotics, and synbiotics and synthesise the similarities and differences among the three effects, 47 meta-analyses with 12 types of neuropsychiatric results were integrated under an umbrella review. Probiotics, prebiotics, and synbiotics intake might all be associated with improvements in some neuropsychiatric outcomes, including neuropsychological test outcomes (probiotic and prebiotic), hepatic encephalopathy outcomes (probiotic, prebiotic, and synbiotic), instant memory in patients with Alzheimer’s disease (probiotic), depressive symptoms (probiotic, prebiotic and synbiotic), mood states and psychiatric distress (probiotic), overall mental health (probiotic), neurological function (probiotic), brain-derived neurotrophic factor (BDNF) concentration (probiotic and synbiotic), and Pittsburgh Sleep Quality Index (PSQI) score (probiotic). All three are similar in that the intake of probiotics, prebiotics, and synbiotics might be associated with improvements in hepatic encephalopathy outcomes and depressive symptoms, both probiotic and synbiotic intake might be associated with elevated BDNF concentrations, and both probiotic and prebiotic intake might be associated with improved neuropsychological test results. The difference between the three is that the neuropsychiatric effects of probiotics might be more widespread and be reflected in the fact that probiotic intake might also be associated with improvements in mood states and psychiatric distress, overall mental health, neurological function, Alzheimer’s disease patients’ instant memory, and PSQI score. Probiotics might be the best and most promising option for improving neuropsychiatric outcomes. In the future, in addition to requiring more high-quality meta-analyses, further preclinical studies are needed to explore specific relevant mechanisms and determine true causal relationships.
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Abdurasulova, I.N., Ermolenko, E.I., Matsulevich, A.V., Abdurasulova, K.O., Tarasova, E.A., Kudryavtsev, I.V., Bisaga, G.N., Suvorov, A.N. and Klimenko, V.M., 2016. Effect of probiotic enterococci and glatiramer acetate on the severity of experimental allergic encephalomyelitis in rats. Rossiiskii Fiziologicheskii Zhurnal Imeni IM Sechenova 102: 463-479.
-
Amirani, E., Milajerdi, A., Mirzaei, H., Jamilian, H., Mansournia, M.A., Hallajzadeh, J. and Ghaderi, A., 2020. The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine 49: 102361. https://doi.org/10.1016/j.ctim.2020.102361
-
Aromataris, E., Fernandez, R., Godfrey, C.M., Holly, C., Khalil, H. and Tungpunkom, P., 2015. Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach. International Journal of Evidence-Based Healthcare 13: 132-140. https://doi.org/10.1097/XEB.0000000000000055
-
Bravo, J.A., Forsythe, P., Chew, M.V., Escaravage, E., Savignac, H.M., Dinan, T.G., Bienenstock, J. and Cryan, J.F., 2011. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proceedings of the National Academy of Science of the USA 108: 16050-16055. https://doi.org/10.1073/pnas.1102999108
-
Cao, Q., Yu, C.-B., Yang, S.-G., Cao, H.-C., Chen, P., Deng, M. and Li, L.-J., 2018. Effect of probiotic treatment on cirrhotic patients with minimal hepatic encephalopathy: A meta-analysis. Hepatobiliary and Pancreatic Diseases International 17: 9-16. https://doi.org/10.1016/j.hbpd.2018.01.005
-
Chao, L., Liu, C., Sutthawongwadee, S., Li, Y., Lv, W., Chen, W., Yu, L., Zhou, J., Guo, A., Li, Z. and Guo, S., 2020. Effects of probiotics on depressive or anxiety variables in healthy participants under stress conditions or with a depressive or anxiety diagnosis: a meta-analysis of randomized controlled trials. Frontiers in Neurology 11: 421. https://doi.org/10.3389/fneur.2020.00421
-
Cumpston, M., Li, T., Page, M.J., Chandler, J., Welch, V.A., Higgins, J.P. and Thomas, J., 2019. Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database of Systematic Reviews 10: ED000142. https://doi.org/10.1002/14651858.ED000142
-
Dalal, R., McGee, R.G., Riordan, S.M. and Webster, A.C., 2017. Probiotics for people with hepatic encephalopathy. Cochrane Database of Systematic Reviews 2: CD008716. https://doi.org/10.1002/14651858.CD008716.pub3
-
Delotterie, D., Mathis, C., Cassel, J.-C., Dorner-Ciossek, C. and Marti, A., 2014. Optimization of touchscreen-based behavioral paradigms in mice: implications for building a battery of tasks taxing learning and memory functions. PLoS ONE 9: e100817. https://doi.org/10.1371/journal.pone.0100817
-
Den, H., Dong, X., Chen, M. and Zou, Z., 2020. Efficacy of probiotics on cognition and biomarkers of inflammation and oxidative stress in adults with Alzheimer’s disease or mild cognitive impairment – a meta-analysis of randomized controlled trials. Aging 12: 4010-4039. https://doi.org/10.18632/aging.102810
-
Desai, V., Kozyrskyj, A.L., Lau, S., Sanni, O., Dennett, L., Walter, J. and Ospina, M.B., 2021. Effectiveness of probiotic, prebiotic and synbiotic supplementation to improve perinatal mental health in mothers: a systematic review and meta-analysis. Frontiers in Psychiatry 12: 622181. https://doi.org/10.3389/fpsyt.2021.622181
-
Egger, M., Davey Smith, G., Schneider, M. and Minder, C., 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634. https://doi.org/10.1136/bmj.315.7109.629
-
El Dib, R., Periyasamy, A.G., de Barros, J.L., França, C.G., Senefonte, F.L., Vesentini, G., Alves, M.G.O., da S. Rodrigues, J.V., Gomaa, H., Gomes Júnior, J.R., Costa, L.F., de S. Von Ancken, T., Toneli, C., Suzumura, E.A., Kawakami, C.P., Faustino, E.G., Jorge, E.C., Almeida, J.D. and Kapoor, A., 2021. Probiotics for the treatment of depression and anxiety: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN 45: 75-90. https://doi.org/10.1016/j.clnesp.2021.07.027
-
Foshati, S., Akhlaghi, M. and Babajafari, S., 2022. The effect of pro-/synbiotic supplementation on the brain-derived neurotrophic factor: a systematic review and meta-analysis of randomized controlled trials. Food and Function 13: 8754-8765. https://doi.org/10.1039/d2fo01330d
-
Freeman, M., 2022. The World Mental Health Report: transforming mental health for all. World Psychiatry 21: 391-392. https://doi.org/10.1002/wps.21018
-
Frick, J.-S. and Autenrieth, I.B., 2013. The gut microflora and its variety of roles in health and disease. Current Topics in Microbiology and Immunology 358: 273-289. https://doi.org/10.1007/82_2012_217
-
Global Health Data Exchange (GHDx), 2023. https://ghdx.healthdata.org.
-
Goh, K.K., Liu, Y.-W., Kuo, P.-H., Chung, Y.-C.E., Lu, M.-L. and Chen, C.-H., 2019. Effect of probiotics on depressive symptoms: A meta-analysis of human studies. Psychiatry Research 282: 112568. https://doi.org/10.1016/j.psychres.2019.112568
-
Guyatt, G.H., Oxman, A.D., Vist, G.E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., Schünemann, H.J. and the GRADE Working Group, 2008. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336: 924-926. https://doi.org/10.1136/bmj.39489.470347.AD
-
Hofmeister, M., Clement, F., Patten, S., Li, J., Dowsett, L.E., Farkas, B., Mastikhina, L., Egunsola, O., Diaz, R., Cooke, N.C.A. and Taylor, V.H., 2021. The effect of interventions targeting gut microbiota on depressive symptoms: a systematic review and meta-analysis. CMAJ Open 9: E1195-E1204. https://doi.org/10.9778/cmajo.20200283
-
Holte, K., Krag, A. and Gluud, L.L., 2012. Systematic review and meta-analysis of randomized trials on probiotics for hepatic encephalopathy. Hepatology Research 42: 1008-1015. https://doi.org/10.1111/j.1872-034X.2012.01015.x
-
Huang, R., Wang, K. and Hu, J., 2016. Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials. Nutrients 8: 483. https://doi.org/10.3390/nu8080483
-
Irwin, C., McCartney, D., Desbrow, B. and Khalesi, S., 2020. Effects of probiotics and paraprobiotics on subjective and objective sleep metrics: a systematic review and meta-analysis. European Journal of Clinical Nutrition 74: 1536-1549. https://doi.org/10.1038/s41430-020-0656-x
-
Jakobsen, J.C., Katakam, K.K., Schou, A., Hellmuth, S.G., Stallknecht, S.E., Leth-Møller, K., Iversen, M., Banke, M.B., Petersen, I.J., Klingenberg, S.L., Krogh, J., Ebert, S.E., Timm, A., Lindschou, J. and Gluud, C., 2017. Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and trial sequential analysis. BMC Psychiatry 17: 58. https://doi.org/10.1186/s12888-016-1173-2
-
Jiang, J., Chu, C., Wu, C., Wang, C., Zhang, C., Li, T., Zhai, Q., Yu, L., Tian, F. and Chen, W., 2021. Efficacy of probiotics in multiple sclerosis: a systematic review of preclinical trials and meta-analysis of randomized controlled trials. Food and Function 12: 2354-2377. https://doi.org/10.1039/d0fo03203d
-
Keene, M.S., Eaddy, M.T., Nelson, W.W. and Sarnes, M.W., 2005. Adherence to paroxetine CR compared with paroxetine IR in a Medicare-eligible population with anxiety disorders. American Journal of Managed Care 11: S362-S369.
-
Krüger, J.F., Hillesheim, E., Pereira, A.C.S.N., Camargo, C.Q. and Rabito, E.I., 2021. Probiotics for dementia: a systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews 79: 160-170. https://doi.org/10.1093/nutrit/nuaa037
-
Le Morvan de Sequeira, C., Hengstberger, C., Enck, P. and Mack, I., 2022. Effect of probiotics on psychiatric symptoms and central nervous system functions in human health and disease: a systematic review and meta-analysis. Nutrients 14: 621. https://doi.org/10.3390/nu14030621
-
Leise, M.D., Poterucha, J.J., Kamath, P.S. and Kim, W.R., 2014. Management of hepatic encephalopathy in the hospital. Mayo Clinic Proceedings 89: 241-253. https://doi.org/10.1016/j.mayocp.2013.11.009
-
Li, X., Lv, C., Song, J. and Li, J., 2021. Effect of probiotic supplementation on cognitive function and metabolic status in mild cognitive impairment and Alzheimer’s disease: a meta-analysis. Frontiers in Nutrition 8: 757673. https://doi.org/10.3389/fnut.2021.757673
-
Liu, B., He, Y., Wang, M., Liu, J., Ju, Y., Zhang, Y., Liu, T., Li, L. and Li, Q., 2018. Efficacy of probiotics on anxiety – A meta-analysis of randomized controlled trials. Depression and Anxiety 35: 935-945. https://doi.org/10.1002/da.22811
-
Liu, C., Guo, X. and Chang, X., 2022. Intestinal flora balance therapy based on probiotic support improves cognitive function and symptoms in patients with Alzheimer’s disease: a systematic review and meta-analysis. BioMed Research International 2022: 4806163. https://doi.org/10.1155/2022/4806163
-
Liu, R.T., Walsh, R.F.L. and Sheehan, A.E., 2019. Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials. Neuroscience and Biobehavioral Reviews 102: 13-23. https://doi.org/10.1016/j.neubiorev.2019.03.023
-
Liu, Y.-W., Liu, W.-H., Wu, C.-C., Juan, Y.-C., Wu, Y.-C., Tsai, H.-P., Wang, S. and Tsai, Y.-C., 2016. Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice. Brain Research 1631: 1-12. https://doi.org/10.1016/j.brainres.2015.11.018
-
Luo, M., Li, L., Lu, C.-Z. and Cao, W.-K., 2011. Clinical efficacy and safety of lactulose for minimal hepatic encephalopathy: a meta-analysis. European Journal of Gastroenterology and Hepatology 23: 1250-1257. https://doi.org/10.1097/MEG.0b013e32834d1938
-
Lv, T., Ye, M., Luo, F., Hu, B., Wang, A., Chen, J., Yan, J., He, Z., Chen, F., Qian, C., Zhang, J., Liu, Z. and Ding, Z., 2021. Probiotics treatment improves cognitive impairment in patients and animals: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews 120: 159-172. https://doi.org/10.1016/j.neubiorev.2020.10.027
-
Margolis, K.G., Cryan, J.F. and Mayer, E.A., 2021. The microbiota-gut-brain axis: from motility to mood. Gastroenterology 160: 1486-1501. https://doi.org/10.1053/j.gastro.2020.10.066
-
Marx, W., Scholey, A., Firth, J., D’Cunha, N.M., Lane, M., Hockey, M., Ashton, M.M., Cryan, J.F., O’Neil, A., Naumovski, N., Berk, M., Dean, O.M. and Jacka, F., 2020. Prebiotics, probiotics, fermented foods and cognitive outcomes: A meta-analysis of randomized controlled trials. Neuroscience and Biobehavioral Reviews 118: 472-484. https://doi.org/10.1016/j.neubiorev.2020.07.036
-
McKean, J., Naug, H., Nikbakht, E., Amiet, B. and Colson, N., 2017. Probiotics and subclinical psychological symptoms in healthy participants: a systematic review and meta-analysis. Journal of Alternative and Complementary Medicine 23: 249-258. https://doi.org/10.1089/acm.2016.0023
-
Meng, H.Y.H., Mak, C.C.H., Mak, W.Y., Zuo, T., Ko, H. and Chan, F.K.L., 2022. Probiotic supplementation demonstrates therapeutic potential in treating gut dysbiosis and improving neurocognitive function in age-related dementia. European Journal of Nutrition 61: 1701-1734. https://doi.org/10.1007/s00394-021-02760-4
-
Mestre, L., Carrillo-Salinas, F.J., Feliú, A., Mecha, M., Alonso, G., Espejo, C., Calvo-Barreiro, L., Luque-Garcı́a, J.L., Estevez, H., Villar, L.M. and Guaza, C., 2020. How oral probiotics affect the severity of an experimental model of progressive multiple sclerosis? Bringing commensal bacteria into the neurodegenerative process. Gut Microbes 12: 1813532. https://doi.org/10.1080/19490976.2020.1813532
-
Miranda, M., Morici, J.F., Zanoni, M.B. and Bekinschtein, P., 2019. Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain. Frontiers in Cellular Neuroscience 13: 363. https://doi.org/10.3389/fncel.2019.00363
-
Mirashrafi, S., Hejazi Taghanaki, S.Z., Sarlak, F., Moravejolahkami, A.R., Hojjati Kermani, M.A. and Haratian, M., 2021. Effect of probiotics supplementation on disease progression, depression, general health and anthropometric measurements in relapsing-remitting multiple sclerosis patients: A systematic review and meta-analysis of clinical trials. International Journal of Clinical Practice 75: e14724. https://doi.org/10.1111/ijcp.14724
-
Misera, A., Liśkiewicz, P., Łoniewski, I., Skonieczna-Żydecka, K. and Samochowiec, J., 2021. Effect of psychobiotics on psychometric tests and inflammatory markers in major depressive disorder: meta-analysis of randomized controlled trials with meta-regression. Pharmaceuticals 14: 952. https://doi.org/10.3390/ph14100952
-
Ng, Q.X., Peters, C., Ho, C.Y.X., Lim, D.Y. and Yeo, W.-S., 2018. A meta-analysis of the use of probiotics to alleviate depressive symptoms. Journal of Affective Disorders 228: 13-19. https://doi.org/10.1016/j.jad.2017.11.063
-
Ng, Q.X., Soh, A.Y.S., Venkatanarayanan, N., Ho, C.Y.X., Lim, D.Y. and Yeo, W.-S., 2019. A systematic review of the effect of probiotic supplementation on schizophrenia symptoms. Neuropsychobiology 78: 1-6. https://doi.org/10.1159/000498862
-
Nikolova, V.L., Cleare, A.J., Young, A.H. and Stone, J.M., 2021. Updated review and meta-analysis of probiotics for the treatment of clinical depression: adjunctive vs. stand-alone treatment. Journal of Clinical Medicine 10: 647. https://doi.org/10.3390/jcm10040647
-
Papatheodorou, S., 2019. Umbrella reviews: what they are and why we need them. European Journal of Epidemiology 34: 543-546. https://doi.org/10.1007/s10654-019-00505-6
-
Parohan, M., Djalali, M., Sarraf, P., Yaghoubi, S., Seraj, A., Foroushani, A.R., Ranji-Burachaloo, S. and Javanbakht, M.H., 2022. Effect of probiotic supplementation on migraine prophylaxis: a systematic review and meta-analysis of randomized controlled trials. Nutritional Neuroscience 25: 511-518. https://doi.org/10.1080/1028415X.2020.1764292
-
Perry, R., Whitmarsh, A., Leach, V. and Davies, P., 2021. A comparison of two assessment tools used in overviews of systematic reviews: ROBIS versus AMSTAR-2. Systematic Reviews 10: 273. https://doi.org/10.1186/s13643-021-01819-x
-
Podvin, S., Jones, A., Liu, Q., Aulston, B., Ransom, L., Ames, J., Shen, G., Lietz, C.B., Jiang, Z., O’Donoghue, A.J., Winston, C., Ikezu, T., Rissman, R.A., Yuan, S. and Hook, V., 2020. Dysregulation of exosome cargo by mutant tau expressed in human-induced pluripotent stem cell (iPSC) neurons revealed by proteomics analyses. Molecular and Cellular Proteomics 19: 1017-1034. https://doi.org/10.1074/mcp.RA120.002079
-
Pratap Mouli, V., Benjamin, J., Bhushan Singh, M., Mani, K., Garg, S.K., Saraya, A. and Joshi, Y.K., 2015. Effect of probiotic VSL#3 in the treatment of minimal hepatic encephalopathy: A non-inferiority randomized controlled trial. Hepatology Research 45: 880-889. https://doi.org/10.1111/hepr.12429
-
Reis, D.J., Ilardi, S.S. and Punt, S.E.W., 2018. The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature. PLoS ONE 13: e0199041. https://doi.org/10.1371/journal.pone.0199041
-
Rogers, J.P. and David, A.S., 2021. A longer look at COVID-19 and neuropsychiatric outcomes. The Lancet Psychiatry 8: 351-352. https://doi.org/10.1016/S2215-0366(21)00120-6
-
Romo-Araiza, A., Gutiérrez-Salmeán, G., Galván, E.J., Hernández-Frausto, M., Herrera-López, G., Romo-Parra, H., Garcı́a-Contreras, V., Fernández-Presas, A.M., Jasso-Chávez, R., Borlongan, C.V. and Ibarra, A., 2018. Probiotics and prebiotics as a therapeutic strategy to improve memory in a model of middle-aged rats. Frontiers in Aging Neuroscience 10: 416. https://doi.org/10.3389/fnagi.2018.00416
-
Ruiz-Gonzalez, C., Roman, P., Rueda-Ruzafa, L., Rodriguez-Arrastia, M. and Cardona, D., 2021. Effects of probiotics supplementation on dementia and cognitive impairment: A systematic review and meta-analysis of preclinical and clinical studies. Progress in Neuro-Psychopharmacology and Biological Psychiatry 108: 110189. https://doi.org/10.1016/j.pnpbp.2020.110189
-
Rynearson, K.D., Ponnusamy, M., Prikhodko, O., Xie, Y., Zhang, C., Nguyen, P., Hug, B., Sawa, M., Becker, A., Spencer, B., Florio, J., Mante, M., Salehi, B., Arias, C., Galasko, D., Head, B.P., Johnson, G., Lin, J.H., Duddy, S.K., Rissman, R.A. and Wagner, S.L., 2021. Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention. Journal of Experimental Medicine 218: e20202560. https://doi.org/10.1084/jem.20202560
-
Saab, S., Suraweera, D., Au, J., Saab, E.G., Alper, T.S. and Tong, M.J., 2016. Probiotics are helpful in hepatic encephalopathy: a meta-analysis of randomized trials. Liver International 36: 986-993. https://doi.org/10.1111/liv.13005
-
Sanada, K., Nakajima, S., Kurokawa, S., Barceló-Soler, A., Ikuse, D., Hirata, A., Yoshizawa, A., Tomizawa, Y., Salas-Valero, M., Noda, Y., Mimura, M., Iwanami, A. and Kishimoto, T., 2020. Gut microbiota and major depressive disorder: A systematic review and meta-analysis. Journal of Affective Disorders 266: 1-13. https://doi.org/10.1016/j.jad.2020.01.102
-
Schmidt, C., 2015. Mental health: thinking from the gut. Nature 518: S12-S15. https://doi.org/10.1038/518S13a
-
Shea, B.J., Grimshaw, J.M., Wells, G.A., Boers, M., Andersson, N., Hamel, C., Porter, A.C., Tugwell, P., Moher, D. and Bouter, L.M., 2007. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Medical Research Methodology 7: 10. https://doi.org/10.1186/1471-2288-7-10
-
Shea, B.J., Reeves, B.C., Wells, G., Thuku, M., Hamel, C., Moran, J., Moher, D., Tugwell, P., Welch, V., Kristjansson, E. and Henry, D.A., 2017. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ 358: j4008. https://doi.org/10.1136/bmj.j4008
-
Shukla, S., Shukla, A., Mehboob, S. and Guha, S., 2011. Meta-analysis: the effects of gut flora modulation using prebiotics, probiotics and synbiotics on minimal hepatic encephalopathy. Alimentary Pharmacology and Therapeutics 33: 662-671. https://doi.org/10.1111/j.1365-2036.2010.04574.x
-
Song, W., Zhang, M., Teng, L., Wang, Y. and Zhu, L., 2022. Prebiotics and probiotics for autism spectrum disorder: a systematic review and meta-analysis of controlled clinical trials. Journal of Medical Microbiology 71: 10.1099/jmm.0.001510. https://doi.org/10.1099/jmm.0.001510
-
Staffaroni, A.M., Asken, B.M., Casaletto, K.B., Fonseca, C., You, M., Rosen, H.J., Boxer, A.L., Elahi, F.M., Kornak, J., Mungas, D. and Kramer, J.H., 2021. Development and validation of the Uniform Data Set (v3.0) executive function composite score (UDS3-EF). Alzheimer’s and Dementia 17: 574-583. https://doi.org/10.1002/alz.12214
-
Takada, M., Nishida, K., Kataoka-Kato, A., Gondo, Y., Ishikawa, H., Suda, K., Kawai, M., Hoshi, R., Watanabe, O., Igarashi, T., Kuwano, Y., Miyazaki, K. and Rokutan, K., 2016. Probiotic Lactobacillus casei strain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models. Neurogastroenterology and Motility 28: 1027-1036. https://doi.org/10.1111/nmo.12804
-
Takahashi, A., Anzai, Y., Kuroda, M., Kokubun, M., Kondo, Y., Ogata, T., Fujita, M., Hayashi, M., Imaizumi, H., Abe, K., Tanji, N. and Ohira, H., 2020. Effects of sleep quality on non-alcoholic fatty liver disease: a cross-sectional survey. BMJ Open 10: e039947. https://doi.org/10.1136/bmjopen-2020-039947
-
Thorsteinsdottir, F., Walker, K.C., Runstedt, S.E., Jacobsen, R., Maslova, E., Backer, V., Heitmann, B.L. and Händel, M.N., 2022. The role of prenatal vitamin D on the development of childhood asthma and wheeze: An umbrella review of systematic reviews and meta-analyses. Clinical Nutrition 41: 1808-1817. https://doi.org/10.1016/j.clnu.2022.06.040
-
Upadhyay, R.P., Taneja, S., Chowdhury, R., Strand, T.A. and Bhandari, N., 2020. Effect of prebiotic and probiotic supplementation on neurodevelopment in preterm very low birth weight infants: findings from a meta-analysis. Pediatric Research 87: 811-822. https://doi.org/10.1038/s41390-018-0211-9
-
Van de Wouw, M., Boehme, M., Lyte, J.M., Wiley, N., Strain, C., O’Sullivan, O., Clarke, G., Stanton, C., Dinan, T.G. and Cryan, J.F., 2018. Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations. Journal of Physiology 596: 4923-4944. https://doi.org/10.1113/JP276431
-
Van Straten, G., de Sain-van der Velden, M.G.M., van Geijlswijk, I.M., Favier, R.P., Mesu, S.J., Holwerda-Loof, N.E., van der Ham, M., Fieten, H., Rothuizen, J., Spee, B. and Verhoeven-Duif, N.M., 2017. Saline is as effective as nitrogen scavengers for treatment of hyperammonemia. Science Reports 7: 13112. https://doi.org/10.1038/s41598-017-12686-9
-
Viramontes Hörner, D., Avery, A. and Stow, R., 2017. The effects of probiotics and symbiotics on risk factors for hepatic encephalopathy: a systematic review. Journal of Clinical Gastroenterology 51: 312-323. https://doi.org/10.1097/MCG.0000000000000789
-
Wallace, C.J.K. and Milev, R., 2017. The effects of probiotics on depressive symptoms in humans: a systematic review. Annals of General Psychiatry 16: 14. https://doi.org/10.1186/s12991-017-0138-2
-
Wang, C., Cai, X., Wang, R., Zhai, S., Zhang, Y., Hu, W., Zhang, Y. and Wang, D., 2020. Neuroprotective effects of verbascoside against Alzheimer’s disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice. Journal of Neuroinflammation 17: 309. https://doi.org/10.1186/s12974-020-01976-1
-
Whiting, P., Savović, J., Higgins, J.P., Caldwell, D.M., Reeves, B.C., Shea, B., Davies, P., Kleijnen, J., Churchill, R. and the ROBIS group, 2016. ROBIS: A new tool to assess risk of bias in systematic reviews was developed. Journal of Clinical Epidemiology 69: 225-234. https://doi.org/10.1016/j.jclinepi.2015.06.005
-
World Health Organization (WHO), 2017. Depression and other common mental disorders: global health estimates. World Health Organization, Geneva, Switzerland.
-
Xu, J., Ma, R., Chen, L.-F., Zhao, L.-J., Chen, K. and Zhang, R.-B., 2014. Effects of probiotic therapy on hepatic encephalopathy in patients with liver cirrhosis: an updated meta-analysis of six randomized controlled trials. Hepatobiliary and Pancreatic Diseases International 13: 354-360. https://doi.org/10.1016/s1499-3872(14)60280-0
-
Zagórska, A., Marcinkowska, M., Jamrozik, M., Wiśniowska, B. and Paśko, P., 2020. From probiotics to psychobiotics – the gut-brain axis in psychiatric disorders. Beneficial Microbes 11: 717-732. https://doi.org/10.3920/BM2020.0063
-
Zhang, N., Zhang, Y., Li, M., Wang, W., Liu, Z., Xi, C., Huang, X., Liu, J., Huang, J., Tian, D., Mu, J., Liao, X. and Zhai, S., 2020. Efficacy of probiotics on stress in healthy volunteers: A systematic review and meta-analysis based on randomized controlled trials. Brain and Behaviour 10: e01699. https://doi.org/10.1002/brb3.1699
-
Zhang, Y.-J., Li, S., Gan, R.-Y., Zhou, T., Xu, D.-P. and Li, H.-B., 2015. Impacts of gut bacteria on human health and diseases. International Journal of Molecular Sciences 16: 7493-7519. https://doi.org/10.3390/ijms16047493
-
Zhao, L.-N., Yu, T., Lan, S.-Y., Hou, J.-T., Zhang, Z.-Z., Wang, S.-S. and Liu, F.-B., 2015. Probiotics can improve the clinical outcomes of hepatic encephalopathy: An update meta-analysis. Clinics and Research in Hepatology and Gastroenterology 39: 674-682. https://doi.org/10.1016/j.clinre.2015.03.008
-
Zhong, D.-Y., Li, L., Ma, R.-M. and Deng, Y.-H., 2021. The effect of probiotics in stroke treatment. Evidence-Based Complementary and Alternative Medicine 2021: 4877311. https://doi.org/10.1155/2021/4877311
-
Zhu, G., Zhao, J., Zhang, H., Chen, W. and Wang, G., 2021. Probiotics for mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis. Foods 10: 1672. https://doi.org/10.3390/foods10071672
-
Zhu, H.Y., Tian, P.J., Zhao, J.X., Zhang, H., Wang, G. and Chen, W., 2022. A psychobiotic approach to the treatment of depression: A systematic review and meta-analysis. Journal of Functional Foods 91: 104999.
-
Zucker, D.M. and Redulla, R., 2019. Lactulose management of minimal hepatic encephalopathy: a systematic review. Gastroenterology Nursing 42: 84-94. https://doi.org/10.1097/SGA.0000000000000429
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Probiotics/prebiotics/synbiotics and human neuropsychiatric outcomes: an umbrella review
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Abstract
The neuropsychiatric effects of probiotics, prebiotics, and synbiotics have been gaining attention since the rise of microbial-gut-brain axis research. Nevertheless, some of the findings are inconsistent, and few studies have analysed the similarities and differences in the neuropsychiatric effects of the three comprehensively. To reveal the respective neuropsychiatric effects of probiotics, prebiotics, and synbiotics and synthesise the similarities and differences among the three effects, 47 meta-analyses with 12 types of neuropsychiatric results were integrated under an umbrella review. Probiotics, prebiotics, and synbiotics intake might all be associated with improvements in some neuropsychiatric outcomes, including neuropsychological test outcomes (probiotic and prebiotic), hepatic encephalopathy outcomes (probiotic, prebiotic, and synbiotic), instant memory in patients with Alzheimer’s disease (probiotic), depressive symptoms (probiotic, prebiotic and synbiotic), mood states and psychiatric distress (probiotic), overall mental health (probiotic), neurological function (probiotic), brain-derived neurotrophic factor (BDNF) concentration (probiotic and synbiotic), and Pittsburgh Sleep Quality Index (PSQI) score (probiotic). All three are similar in that the intake of probiotics, prebiotics, and synbiotics might be associated with improvements in hepatic encephalopathy outcomes and depressive symptoms, both probiotic and synbiotic intake might be associated with elevated BDNF concentrations, and both probiotic and prebiotic intake might be associated with improved neuropsychological test results. The difference between the three is that the neuropsychiatric effects of probiotics might be more widespread and be reflected in the fact that probiotic intake might also be associated with improvements in mood states and psychiatric distress, overall mental health, neurological function, Alzheimer’s disease patients’ instant memory, and PSQI score. Probiotics might be the best and most promising option for improving neuropsychiatric outcomes. In the future, in addition to requiring more high-quality meta-analyses, further preclinical studies are needed to explore specific relevant mechanisms and determine true causal relationships.
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