Save

Effect of pre- and probiotics on liver regeneration after resection: a randomised, double-blind pilot study

In: Beneficial Microbes
Authors:
N. Rayes 1Department of General-, Visceral- and Transplant Surgery, Charité Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
nada.rayes@charite.de

Search for other papers by N. Rayes in
Current site
Google Scholar
PubMed
Close
,
T. Pilarski 1Department of General-, Visceral- and Transplant Surgery, Charité Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany

Search for other papers by T. Pilarski in
Current site
Google Scholar
PubMed
Close
,
M. Stockmann 1Department of General-, Visceral- and Transplant Surgery, Charité Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany

Search for other papers by M. Stockmann in
Current site
Google Scholar
PubMed
Close
,
S. Bengmark 2Division of Surgery and Interventional Science, University College, Gower Street, WC1E 6BT London, United Kingdom

Search for other papers by S. Bengmark in
Current site
Google Scholar
PubMed
Close
,
P. Neuhaus 1Department of General-, Visceral- and Transplant Surgery, Charité Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany

Search for other papers by P. Neuhaus in
Current site
Google Scholar
PubMed
Close
, and
D. Seehofer 1Department of General-, Visceral- and Transplant Surgery, Charité Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany

Search for other papers by D. Seehofer in
Current site
Google Scholar
PubMed
Close
Download Citation Get Permissions

Access options

Get access to the full article by using one of the access options below.

Institutional Login

Log in with Open Athens, Shibboleth, or your institutional credentials

Login via Institution

Purchase

Buy instant access (PDF download and unlimited online access):

$40.00

Abstract

Liver regeneration is a prerequisite for extended liver surgery. Several studies have shown that the bacterial gut flora is able to modulate liver function. Previously we observed that synbiotics could partly reverse the impaired mitosis rate of hepatocytes in a rat model of synchronous liver resection and colon anastomosis. The effect of synbiotics on liver function after hepatic resection has not been analysed yet. A prospective randomised double-blind pilot trial was undertaken in 19 patients scheduled for right hepatectomy. All patients received enteral nutrition immediately post-operatively. Comparison was made between a group receiving a combination of four probiotics and four fibres and a placebo group receiving the fibres only starting the day before surgery and continuing for 10 days. Primary study endpoint was the liver function capacity measured by 13C-methacetin breath test and indocyanine green plasma disappearance rate. Portal vein flow, liver volumetry, laboratory parameters for liver function, length of hospital stay, post-operative complications and side effects of synbiotic therapy were recorded. Liver function capacity was comparable in both groups. Complications had a negative impact on liver function. Because complications were more severe in the verum group, a sub-analysis was performed. In case of an uncomplicated course, liver function capacity was better in the patients with synbiotics. No severe side effects occurred. Synbiotics might be able to increase liver function capacity in patients after liver resection, but patient numbers were too small and the clinical courses too heterogeneous to draw any definite conclusions.

Content Metrics

All Time Past Year Past 30 Days
Abstract Views 84 84 24
Full Text Views 7 2 0
PDF Views & Downloads 5 5 0