Bifidobacterium fermented milk and galacto-oligosaccharides lead to improved skin health by decreasing phenols production by gut microbiota
In: Beneficial MicrobesSearch for other papers by K. Miyazaki in
Current site
Google Scholar
Search for other papers by N. Masuoka in
Current site
Google Scholar
Search for other papers by M. Kano in
Current site
Google Scholar
Search for other papers by R. Iizuka in
Current site
Google Scholar
A questionnaire survey found that women suffering from abnormal bowel movements have many skin problems such as a high frequency of dry skin. Although there are similarities between the structure and barrier function mechanism of the gut and skin, experimental data are insufficient to show an association between the intestinal environment and skin conditions. Phenols, for example phenol and p-cresol, as metabolites of aromatic amino acids produced by gut bacteria, are regarded as bioactive toxins and serum biomarkers of a disturbed gut environment. Recent studies have demonstrated that phenols disturb the differentiation of monolayer-cultured keratinocytes in vitro, and that phenols produced by gut bacteria accumulate in the skin via the circulation and disrupt keratinocyte differentiation in hairless mice. Human studies have demonstrated that restriction of probiotics elevated serum free p-cresol levels and harmed skin conditions (reduced skin hydration, disrupted keratinisation). In contrast, daily intake of the prebiotic galacto-oligosaccharides (GOS) restored serum free p-cresol levels and skin conditions in adult women. Moreover, a double-blind placebo-controlled trial demonstrated that the daily intake of fermented milk containing the probiotic Bifidobacterium breve strain Yakult and prebiotic GOS reduced serum total phenol levels and prevented skin dryness and disruption of keratinisation in healthy adult women. It is concluded that phenols produced by gut bacteria are one of the causes of skin problems. Probiotics and/or prebiotics, such as B. breve strain Yakult and/or GOS, are expected to help maintain a healthy skin by decreasing phenols production by gut microbiota. These findings support the hypothesis that probiotics and prebiotics provide health benefits to the skin as well as the gut.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Ara, K., Meguro, S., Hase, T., Tokimitsu, I., Otsuji, K., Kawai, S., Ito, S. and Iino, H., 2002. Effect of spore-bearing lactic acid-forming bacteria (Bacillus coagulans SANK 70258) administration on the intestinal environment, defection frequency, fecal characteristics and dermal characteristics in humans and rats. Microbial Ecology in Health and Disease 14: 4-13.
'Effect of spore-bearing lactic acid-forming bacteria (Bacillus coagulans SANK 70258) administration on the intestinal environment, defection frequency, fecal characteristics and dermal characteristics in humans and rats ' () 14 Microbial Ecology in Health and Disease : 4 -13 .
-
Bone, E., Tamm, A. and Hill, M., 1976. The production of urinary phenols by gut bacteria and their possible role in the causation of large bowel cancer. American Journal of Clinical Nutrition 29: 1448-1454.
'The production of urinary phenols by gut bacteria and their possible role in the causation of large bowel cancer ' () 29 American Journal of Clinical Nutrition : 1448 -1454 .
-
Cheng, T., Hitomi, K., Van Vlijmen-Willems, I.M.J.J., De Jongh, G.J., Yamamoto, K., Nishi, K., Watts, C., Reinheckel, T., Schalkwijk, J. and Zeeuwen, P.L.J.M. 2006. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site: a novel clue for the role of cystatin M/E in epidermal cornification. Journal of Biological Chemistry 281: 15893-15899.
'Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site: a novel clue for the role of cystatin M/E in epidermal cornification ' () 281 Journal of Biological Chemistry : 15893 -15899 .
-
De Loor, H., Bammens, B., Evenepoel, P., De Preter, V. and Verbeke, K., 2005. Gas chromatographic-mass spectorometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serum. Clinical Chemistry 51: 1535-1538.
'Gas chromatographic-mass spectorometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serum ' () 51 Clinical Chemistry : 1535 -1538 .
-
De Preter, V., Geboes, K., Verbrugghe, K., De Vuyst, L., Vanhoutte, T., Huys, G., Swings, J., Pot, B. and Verbeke, K., 2004. The in vivo use of the stable isotope-labelled biomarkers lactose-[15N]ureide and [2H4]tyrosine to assess the effects of pro- and prebiotics on the intestinal flora of healthy human volunteers. British Journal of Nutrition 92: 439-446.
'The in vivo use of the stable isotope-labelled biomarkers lactose-[15N]ureide and [2H4]tyrosine to assess the effects of pro- and prebiotics on the intestinal flora of healthy human volunteers ' () 92 British Journal of Nutrition : 439 -446 .
-
De Preter, V., Vanhoutte, T., Huys, G., Swings, J., De Vuyst, L., Rutgeerts, P. and Verbeke, K., 2007. Effects of Lactobacillus casei Shirota, Bifidobacterium breve, and oligofructose-enriched inulin on colonic nitrogen-protein metabolism in healthy humans. American Journal of Physiology – Gastrointestinal and Liver Physiology 292: G358-G368.
'Effects of Lactobacillus casei Shirota, Bifidobacterium breve, and oligofructose-enriched inulin on colonic nitrogen-protein metabolism in healthy humans ' () 292 American Journal of Physiology – Gastrointestinal and Liver Physiology : G358 -G368 .
-
Drago, L., Iemoli, E., Rodighiero, V., Nicola, L., De Vecchi, E. and Piconi, S., 2011. Effects of Lactobacillus salivarius LS01 (DSM 22775) treatment on adult atopic dermatitis: a randomized placebo-controlled study. International Journal of Immunopathology and Pharmacology 24: 1037-1048.
'Effects of Lactobacillus salivarius LS01 (DSM 22775) treatment on adult atopic dermatitis: a randomized placebo-controlled study ' () 24 International Journal of Immunopathology and Pharmacology : 1037 -1048 .
-
Ekanayake-Mudiyanselarge, S., Aschauer, H., Schmook, F.P., Jensen, J.M., Meingassner, J.G. and Proksch, E. 1998. Expression of epidermal keratins and the cornified envelope protein involucrin is influenced by permeability barrier disruption. Journal of Investigative Dermatology 111: 517-523.
'Expression of epidermal keratins and the cornified envelope protein involucrin is influenced by permeability barrier disruption ' () 111 Journal of Investigative Dermatology : 517 -523 .
-
Evenepoel, P., Meijers, B.K.I., Bammens, B.R.M. and Verbeke, K., 2009. Uremic toxins originating from colonic microbial metabolism. Kidney International 76: s12-s19.
'Uremic toxins originating from colonic microbial metabolism ' () 76 Kidney International : s12 -s19 .
-
Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO), 2002. Guidelines for the evaluation of probiotics in food. Report of a Joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food. Available at: ftp://ftp.fao.org/es/esn/food/wgreport2.pdf. ftp://ftp.fao.org/es/esn/food/wgreport2.pdf
-
Gibson, G.R. and Roberfroid, M.B., 1995. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Journal of Nutrition 125: 1401-1412.
'Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics ' () 125 Journal of Nutrition : 1401 -1412 .
-
Guéniche, A., Benyacoub, J., Buetler, T.M., Smola, H. and Blum, S., 2006. Supplementation with oral probiotic bacteria maintains cutaneous immune homeostasis after UV exposure. European Journal of Dermatology 16: 511-517.
'Supplementation with oral probiotic bacteria maintains cutaneous immune homeostasis after UV exposure ' () 16 European Journal of Dermatology : 511 -517 .
-
Hacini-Rachinel, F., Gheit, H., Le Luduec, J.B., Dif, F., Nancey, S. and Kaiserlian, D., 2009. Oral probiotic control skin inflammation by acting on both effector and regulatory T cells. PLoS One 4: e4903.
'Oral probiotic control skin inflammation by acting on both effector and regulatory T cells ' () 4 PLoS One : e4903 .
-
Hida, M., Aiba, Y., Sawamura, S., Suzuki, N., Satoh, T. and Koga, Y., 1996. Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis. Nephron 74: 349-355.
'Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis ' () 74 Nephron : 349 -355 .
-
Iizuka, R., 2012. Gut bacteria and skin health. In: Preedy, V.R. (ed.) Handbook of diet, nutrition and the skin. Wageningen Academic Publishers, Wageningen, the Netherlands, pp. 27-44.
Handbook of diet, nutrition and the skin , () 27 -44 .
-
Iizuka, R., Kawakami, K. and Chiba, K., 2009b. Gut bacteria producing phenols disturb keratinocyte differentiation in human skin. Microbial Ecology in Health and Disease 21: 221-227.
'Gut bacteria producing phenols disturb keratinocyte differentiation in human skin ' () 21 Microbial Ecology in Health and Disease : 221 -227 .
-
Iizuka, R., Kawakami, K., Izawa, N. and Chiba, K., 2009a. Phenols produced by gut bacteria affect the skin in hairless mice. Microbial Ecology in Health and Disease 21: 50-56.
'Phenols produced by gut bacteria affect the skin in hairless mice ' () 21 Microbial Ecology in Health and Disease : 50 -56 .
-
Isawa, K., Noma, T., Yamamoto, M., Kimura, K., Ito, H., Takemoto, N., Numano, K. and Kawashima, M., 2008. Verifying the ability of yogurt prepared with LB81 lactic acid bacteria to improve skin function. Journal of Intestinal Microbiology 22: 1-5 [in Japanese].
'Verifying the ability of yogurt prepared with LB81 lactic acid bacteria to improve skin function ' () 22 Journal of Intestinal Microbiology : 1 -5 .
-
Isolauri, E., Arvola Sütas, Y., Moilanen, E. and Salminen S., 2000. Probiotics in the management of atopic eczema. Clinical and Experimental Allergy 30: 1604-1610.
'Probiotics in the management of atopic eczema ' () 30 Clinical and Experimental Allergy : 1604 -1610 .
-
Ito, M., Kimura, M., Deguchi, Y., Miyamori-Watabe, A., Yajima, T. and Kan, T., 1993. Effects of transgalactosylated disaccharides on the human intestinal microflora and their metabolism. Journal of Nutritional Science and Vitaminology 39: 279-288.
'Effects of transgalactosylated disaccharides on the human intestinal microflora and their metabolism ' () 39 Journal of Nutritional Science and Vitaminology : 279 -288 .
-
Ivanov, I.I., Atarashi, K., Manel, N., Brodie, E.L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K.C., Santee, C.A., Lynch, S.V., Tanoue, T., Imaoka, A., Itoh, K., Takeda, K., Umesaki, Y., Honda, K. and Littman, D.R., 2009. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139: 1-14.
'Induction of intestinal Th17 cells by segmented filamentous bacteria ' () 139 Cell : 1 -14 .
-
Kalliomäki, M., Salminen, S., Poussa, T., Arvilommi, H. and Isolauri, E., 2003. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. The Lancet 361: 1869-1871.
'Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial ' () 361 The Lancet : 1869 -1871 .
-
Kano, M., Masuoka, N., Kaga, C., Sugimoto, S., Iizuka, R., Manabe, K., Sone, T., Ooeda, K., Nonaka, C., Miyazaki, K. and Ishikawa, F., 2013. Consecutive intake of fermented milk containing Bifidobacterium breve strain Yakult and galacto-oligosaccharides benefits skin condition in healthy adult women. Bioscience of Microbiota, Food and Health 32: 33-39.
'Consecutive intake of fermented milk containing Bifidobacterium breve strain Yakult and galacto-oligosaccharides benefits skin condition in healthy adult women ' () 32 Bioscience of Microbiota, Food and Health : 33 -39 .
-
Kawano, N., Konno, T., Suzuki, Y., Kawai, M., Takada, T., Setoyama, H., Ikemura, H. and Ueki, Y., 2012. The effect of fermented milk on constipation-prone individuals classified according to the stress level. Japanese Journal of Nutrition and Dietetics 70: 3-16 [in Japanese].
'The effect of fermented milk on constipation-prone individuals classified according to the stress level ' () 70 Japanese Journal of Nutrition and Dietetics : 3 -16 .
-
Lee, S., Park, Y.K., Kim, Y.K. and Kang, J.S., 1983. An experimental study on corneocytes of acutely and chronically irritated skin. Archives of Dermatological Research 275: 49-52.
'An experimental study on corneocytes of acutely and chronically irritated skin ' () 275 Archives of Dermatological Research : 49 -52 .
-
Ley, R.E., Turnbaugh, P.J., Klein, S. and Gordon, J.I., 2006. Microbial ecology: human gut microbes associated with obesity. Nature 444: 1022-1023.
'Microbial ecology: human gut microbes associated with obesity ' () 444 Nature : 1022 -1023 .
-
Masuoka, N., 2012. Probiotics and prebiotics improve gut environment and skin condition. Cosmetic Stage 7: 20-25 [in Japanese].
'Probiotics and prebiotics improve gut environment and skin condition ' () 7 Cosmetic Stage : 20 -25 .
-
Miyazaki, K. and Matsuzaki, T., 2008. Health properties of milk fermented with Lactobacillus casei strain Shirota (LcS). In: Farnworth E.R. (ed.) Handbook of fermented functional foods, 2nd edition. CRC Press, New York, NY, USA, pp. 165-208.
Handbook of fermented functional foods , () 165 -208 .
-
Nakabayashi, I., Nakamura, M., Kawakami, K., Ohta, T., Kato, I., Uchida, K. and Yoshida, M., 2011. Effects of synbiotic treatment on serum level of p-cresol in haemodialysis patients: a preliminary study. Nephrology, Dialysis and Transplantation 26: 1094-1098.
'Effects of synbiotic treatment on serum level of p-cresol in haemodialysis patients: a preliminary study ' () 26 Nephrology, Dialysis and Transplantation : 1094 -1098 .
-
Peguet-Navarro, J., Dezutter-Dambuyant, C., Buetler, T., Leclaire, J., Smola, H., Blum, S., Bastien, P., Breton, L. and Guéniche, A., 2008. Supplementation with oral probiotic bacteria protects human cutaneous immune homeostasis after UV exposure-double blind, randomized, placebo controlled clinical trial. European Journal of Dermatology 18: 504-511.
'Supplementation with oral probiotic bacteria protects human cutaneous immune homeostasis after UV exposure-double blind, randomized, placebo controlled clinical trial ' () 18 European Journal of Dermatology : 504 -511 .
-
Sako, T., Matsumoto, K. and Tanaka, R., 1999. Recent progress on research and applications of non-digestible galacto-oligosaccharides. International Dairy Journal 9: 69-80.
'Recent progress on research and applications of non-digestible galacto-oligosaccharides ' () 9 International Dairy Journal : 69 -80 .
-
Shioiri, T., Yahagi, K., Nakayama, S., Asahara, T., Yuki, N., Kawakami, K., Yamaoka, Y., Sakai, Y., Nomoto, K. and Totani, M., 2006. The effects of a synbiotic fermented milk beverage containing Lactobacillus casei strain Shirota and transgalactosylated oligosaccharides on defecation frequency, intestinal microflora, organic acid concentrations, and putrefactive metabolites of sub-optimal health state volunteers: a randomized placebo-controlled cross-over study. Bioscience and Microflora 25: 137-146.
'The effects of a synbiotic fermented milk beverage containing Lactobacillus casei strain Shirota and transgalactosylated oligosaccharides on defecation frequency, intestinal microflora, organic acid concentrations, and putrefactive metabolites of sub-optimal health state volunteers: a randomized placebo-controlled cross-over study ' () 25 Bioscience and Microflora : 137 -146 .
-
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X.N., Kubo, C. and Koga, Y., 2004. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. Journal of Physiology 558: 263-275.
'Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice ' () 558 Journal of Physiology : 263 -275 .
-
Sugimoto, S., Ishii, Y., Izawa, N., Masuoka, N., Kano, M., Sone, T., Chiba, K., Miyazaki, K. and Ishikawa, F., 2012. Photoprotective effects of Bifidobacterium breve supplementation against skin damage induced by ultraviolet irradiation in hairless mice. Photodermatology, Photoimmunology and Photomedicine 28: 312-319.
'Photoprotective effects of Bifidobacterium breve supplementation against skin damage induced by ultraviolet irradiation in hairless mice ' () 28 Photodermatology, Photoimmunology and Photomedicine : 312 -319 .
-
Umesaki, Y., Matsumoto, K., Asahara, T., Onoue, M., Kawakami, K., Nanno M., Shida, K., Matsumoto, S., Ishikawa, F., Iino, T., Sawada, H., Shima, T., Ishikawa E., Imaoka, A., Takahashi, T., Morotomi, M. and Nomoto, K., 2012. Health-promoting effects of B. breve strain Yakult and B. bifidum strain Yakult. In: Yakult Central Institute for Microbiological Research (ed.), Advances in the science of Bifidobacterium Yakult strains – intestinal microbiota and human health. Yakult Honsha, Tokyo, Japan, pp. 145-298.
-
Wikoff, W.R., Anfora, A.T., Liu, J., Schultz, P.G., Lesley, S.A., Peters, E.C. and Siuzdak, G., 2009. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proceedings of the National Academy of Sciences of the USA 106: 3698-3703.
'Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites ' () 106 Proceedings of the National Academy of Sciences of the USA : 3698 -3703 .
-
Wu, M.J., Chang, C.S., Cheng, C.H., Chen, C.H., Lee, W.C., Hsu, Y.H., Shu, K.H. and Tang, M.J, 2004. Colonic transit time in long-term dialysis patients. American Journal of Kidney Diseases 44, 322-327.
'Colonic transit time in long-term dialysis patients ' () 44 American Journal of Kidney Diseases : 322 -327 .
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 970 | 775 | 87 |
| Full Text Views | 39 | 31 | 5 |
| PDF Views & Downloads | 43 | 32 | 4 |
Bifidobacterium fermented milk and galacto-oligosaccharides lead to improved skin health by decreasing phenols production by gut microbiota
In: Beneficial MicrobesSearch for other papers by K. Miyazaki in
Current site
Google Scholar
PubMed
Search for other papers by N. Masuoka in
Current site
Google Scholar
PubMed
Search for other papers by M. Kano in
Current site
Google Scholar
PubMed
Search for other papers by R. Iizuka in
Current site
Google Scholar
PubMed
A questionnaire survey found that women suffering from abnormal bowel movements have many skin problems such as a high frequency of dry skin. Although there are similarities between the structure and barrier function mechanism of the gut and skin, experimental data are insufficient to show an association between the intestinal environment and skin conditions. Phenols, for example phenol and p-cresol, as metabolites of aromatic amino acids produced by gut bacteria, are regarded as bioactive toxins and serum biomarkers of a disturbed gut environment. Recent studies have demonstrated that phenols disturb the differentiation of monolayer-cultured keratinocytes in vitro, and that phenols produced by gut bacteria accumulate in the skin via the circulation and disrupt keratinocyte differentiation in hairless mice. Human studies have demonstrated that restriction of probiotics elevated serum free p-cresol levels and harmed skin conditions (reduced skin hydration, disrupted keratinisation). In contrast, daily intake of the prebiotic galacto-oligosaccharides (GOS) restored serum free p-cresol levels and skin conditions in adult women. Moreover, a double-blind placebo-controlled trial demonstrated that the daily intake of fermented milk containing the probiotic Bifidobacterium breve strain Yakult and prebiotic GOS reduced serum total phenol levels and prevented skin dryness and disruption of keratinisation in healthy adult women. It is concluded that phenols produced by gut bacteria are one of the causes of skin problems. Probiotics and/or prebiotics, such as B. breve strain Yakult and/or GOS, are expected to help maintain a healthy skin by decreasing phenols production by gut microbiota. These findings support the hypothesis that probiotics and prebiotics provide health benefits to the skin as well as the gut.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 970 | 775 | 87 |
| Full Text Views | 39 | 31 | 5 |
| PDF Views & Downloads | 43 | 32 | 4 |
