Effect of fermented milk containing Lactobacillus casei strain Shirota on constipation-related symptoms and haemorrhoids in women during puerperium
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Constipation and haemorrhoids are common complaints after childbirth. The objective of this pilot study was to evaluate impact of fermented milk containing Lactobacillus casei strain Shirota (LcS) on stool consistency and frequency, constipation-related symptoms and quality of life, and incidence of haemorrhoids in women during puerperium. Forty women who had natural childbirth were randomised to group consuming either one bottle/day of fermented milk containing at least 6.5×109 cfu of LcS, or placebo, for 6 weeks after childbirth. Subjects filled in a diary on their bowel habits including number of bowel movement, stool consistency and incidence of haemorrhoids, and answered questionnaires on constipation-related symptoms (PAC-SYM) and quality of life (PAC-QOL) during the study period. The probiotic group showed the better scores on overall PAC-SYM (P=0.013), PAC-SYM subscales of abdominal symptoms (P=0.043) and rectal symptoms (P=0.031), and PAC-QOL satisfaction subscale (P=0.037) in comparison with the placebo group. In the probiotic group, two to four subjects experienced haemorrhoids during the first 3 weeks of treatment. The number decreased in week 4 and no one had haemorrhoids on most days in week 5-6. In the placebo group, on average four subjects had haemorrhoids from the beginning, and no obvious change was observed until week 6. No statistically significant effect was observed on stool consistency and frequency. The study products did not cause any adverse event in the subjects. Results of this study indicate that continuous consumption of fermented milk containing LcS might alleviate constipation-related symptoms, provide satisfactory bowel habit and result in earlier recovery from haemorrhoids in women during puerperium. Nonetheless, there are several limitations in interpretation of the results attributed to the study design, including lack of baseline data. Further study is required in order to confirm the efficacy.
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-
Abramowitz, L., Sobhani, I., Benifla, J.L., Vuagnat, A., Daraï, E., Mignon, M. and Madelenat, P., 2002. Anal fissure and thrombosed external haemorrhoids before and after delivery. Diseases of the Colon and Rectum 45: 650-655.
'Anal fissure and thrombosed external haemorrhoids before and after delivery ' () 45 Diseases of the Colon and Rectum : 650 -655.
-
Avsar, A.F. and Keskin, H.L., 2010. Haemorrhoids during pregnancy. Journal of Obstetrics and Gynaecology 30: 231-237.
'Haemorrhoids during pregnancy ' () 30 Journal of Obstetrics and Gynaecology : 231 -237.
-
Bradley, C.S., Kennedy, C.M., Turcea, A.M., Rao, S.S. and Nygaard, I.E., 2007. Constipation in pregnancy: prevalence, symptoms, and risk factors. Obstetrics and Gynecology 110: 1351-1357.
'Constipation in pregnancy: prevalence, symptoms, and risk factors ' () 110 Obstetrics and Gynecology : 1351 -1357.
-
Chmielewska, A. and Szajewska, H., 2010. Systematic review of randomized controlled trials: probiotics for functional constipation. World Journal of Gastroenterology 16: 69-75.
'Systematic review of randomized controlled trials: probiotics for functional constipation ' () 16 World Journal of Gastroenterology : 69 -75.
-
Cullen, G. and O’Donoghue, D., 2007. Constipation and pregnancy. Best Practice and Research Clinical Gastroenterology 21: 807-818.
'Constipation and pregnancy ' () 21 Best Practice and Research Clinical Gastroenterology : 807 -818.
-
Dennison, A.R., Paraskevopoulos, J.A., Kerrigan, D.D. and Shorthouse, A.J., 1996. New thoughts on the aetiology of haemorrhoids and the development of non-operative methods for their management. Minerva Chirurgica 51: 209-216.
'New thoughts on the aetiology of haemorrhoids and the development of non-operative methods for their management ' () 51 Minerva Chirurgica : 209 -216.
-
Derbyshire, E., Davies, J., Costarelli, V. and Dettmar, P., 2006. Diet, physical inactivity and the prevalence of constipation throughout and after pregnancy. Maternal and Child Nutrition 2: 127-134.
'Diet, physical inactivity and the prevalence of constipation throughout and after pregnancy ' () 2 Maternal and Child Nutrition : 127 -134.
-
Derbyshire, E.J., Davies, J. and Detmar, P., 2007. Changes in bowel function: pregnancy and the puerperium. Digestive Diseases and Sciences 52: 324-328.
'Changes in bowel function: pregnancy and the puerperium ' () 52 Digestive Diseases and Sciences : 324 -328.
-
Fateh, R., Iravani, S., Frootan, M., Rasouli, M.R. and Saadat, S., 2011. Synbiotic preparation in men suffering from functional constipation: a randomized controlled trial. Swiss Medical Weekly 141: w13239.
'Synbiotic preparation in men suffering from functional constipation: a randomized controlled trial ' () 141 Swiss Medical Weekly : w13239.
-
Frank, L., Kleinman, L., Farup, C., Taylor, L. and Miner, Jr., P., 1999. Psychometric validation of a constipation symptom assessment questionnaire. Scandinavian Journal of Gastroenterology 34: 870-877.
'Psychometric validation of a constipation symptom assessment questionnaire ' () 34 Scandinavian Journal of Gastroenterology : 870 -877.
-
Gjerdingen, D.K., Froberg, D.G., Chaloner, K.M. and McGovern, P.M., 1993. Changes in women's physical health during the first postpartum year. Archives of Family Medicine 2: 277-283.
'Changes in women's physical health during the first postpartum year ' () 2 Archives of Family Medicine : 277 -283.
-
Heaton, K.W., Radvan, J., Cripps, H., Mountford, R.A., Braddon, F.E. and Hughes, A.O., 1992. Defecation frequency and timing, and stool form in the general population: a prospective study. Gut 33: 818-824.
'Defecation frequency and timing, and stool form in the general population: a prospective study ' () 33 Gut : 818 -824.
-
Hibberts, F. and Schizas, A., 2010. Assessment and treatment of patients with haemorrhoids. Nursing Standard 24: 51-56.
'Assessment and treatment of patients with haemorrhoids ' () 24 Nursing Standard : 51 -56.
-
Kamm, M.A., Mueller-Lissner, S., Wald, A., Richter, E., Swallow, R. and Gessner, U., 2011. Oral bisacodyl is effective and well-tolerated in patients with chronic constipation. Clinical Gastroenterology and Hepatology 9: 577-583.
'Oral bisacodyl is effective and well-tolerated in patients with chronic constipation ' () 9 Clinical Gastroenterology and Hepatology : 577 -583.
-
Koebnick, C., Wagner, I., Leitzmann, P., Stern, U. and Zunft, H.J., 2003. Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Canadian Journal of Gastroenterology 17: 655-659.
'Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation ' () 17 Canadian Journal of Gastroenterology : 655 -659.
-
Liu, N., Mao, L., Sun, X., Liu, L., Yao, P. and Chen, B., 2009. The effect of health and nutrition education intervention on women's postpartum beliefs and practices: a randomized controlled trial. BMC Public Health 9: 45.
'The effect of health and nutrition education intervention on women's postpartum beliefs and practices: a randomized controlled trial ' () 9 BMC Public Health : 45.
-
Loder, P.B., Kamm, M.A., Nicholls, R.J. and Phillips, R.K., 1994. Haemorrhoids: pathology, pathophysiology and aetiology. British Journal of Surgery 81: 946-954.
'Haemorrhoids: pathology, pathophysiology and aetiology ' () 81 British Journal of Surgery : 946 -954.
-
Marquis, P., De La Loge, C., Dubois, D., McDermott, A. and Chassany, O., 2005. Development and validation of the patient assessment of constipation quality of life questionnaire. Scandinavian Journal of Gastroenterology 40: 540-551.
'Development and validation of the patient assessment of constipation quality of life questionnaire ' () 40 Scandinavian Journal of Gastroenterology : 540 -551.
-
Marshall, K., Thompson, K.A., Walsh, D.M. and Baxter, G.D., 1998. Incidence of urinary incontinence and constipation during pregnancy and postpartum: survey of current findings at the rotunda lying-in hospital. British Journal of Obstetrics and Gynaecology 105: 400-402.
'Incidence of urinary incontinence and constipation during pregnancy and postpartum: survey of current findings at the rotunda lying-in hospital ' () 105 British Journal of Obstetrics and Gynaecology : 400 -402.
-
Matsumoto, K., Takada, T., Shimizu, K., Kado, Y., Kawakami, K., Makino, I., Yamaoka, Y., Hirano, K., Nishimura, A., Kajimoto, O. and Nomoto, K., 2006. The effects of a probiotic milk product containing Lactobacillus casei strain Shirota on the defecation frequency and the intestinal microflora of sub-optimal health state volunteers: a randomized placebo-controlled cross-over study. Bioscience and Microflora 25: 39-48.
'The effects of a probiotic milk product containing Lactobacillus casei strain Shirota on the defecation frequency and the intestinal microflora of sub-optimal health state volunteers: a randomized placebo-controlled cross-over study ' () 25 Bioscience and Microflora : 39 -48.
-
Mazlyn, M.M., Nagarajah, L.H., Fatimah, A., Norimah, A.K. and Goh, K.L., 2013. Effects of a probiotic fermented milk on functional constipation: a randomized, double-blind, placebo-controlled study. Journal of Gastroenterology and Hepatology 28: 1141-1147.
'Effects of a probiotic fermented milk on functional constipation: a randomized, double-blind, placebo-controlled study ' () 28 Journal of Gastroenterology and Hepatology : 1141 -1147.
-
Müller-Lissner, S., Kamm, M.A., Wald, A., Hinkel, U., Koehler, U., Richter, E. and Bubeck, J., 2010a. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. American Journal of Gastroenterology 105: 897-903.
'Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation ' () 105 American Journal of Gastroenterology : 897 -903.
-
Müller-Lissner, S., Rykx, A., Kerstens, R. and Vandeplassche, L., 2010b. A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation. Neurogastroenterology and Motility 22: 991-998.
'A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation ' () 22 Neurogastroenterology and Motility : 991 -998.
-
O’Boyle, A.L., O’Boyle, J.D., Magann, E.F., Rieg, T.S., Morrison, J.C. and Davis, G.D., 2008. Anorectal symptoms in pregnancy and the postpartum period. Journal of Reproductive Medicine 53: 151-154.
'Anorectal symptoms in pregnancy and the postpartum period ' () 53 Journal of Reproductive Medicine : 151 -154.
-
O’Brien, C.E., Anderson, P.J. and Stowe, C.D., 2011. Lubiprostone for constipation in adults with cystic fibrosis: a pilot study. Annals of Pharmacotherapy 45: 1061-1066.
'Lubiprostone for constipation in adults with cystic fibrosis: a pilot study ' () 45 Annals of Pharmacotherapy : 1061 -1066.
-
O’Donnell, L.J., Virjee, J. and Heaton, K.W., 1990. Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate. BMJ 300: 439-440.
'Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate ' () 300 BMJ : 439 -440.
-
Saha, S., Manlolo, J., McGowan, C.E., Reinert, S. and Esposti, S.D., 2011. Gastroenterology consultations in pregnancy. Journal of Women's Health 20: 359-363.
'Gastroenterology consultations in pregnancy ' () 20 Journal of Women's Health : 359 -363.
-
Sakai, T., Makino, H., Ishikawa, E., Oishi, K. and Kushiro, A., 2011. Fermented milk containing Lactobacillus casei strain Shirota reduces incidence of hard or lumpy stools in healthy population. International Journal of Food Sciences and Nutrition 62: 423-430.
'Fermented milk containing Lactobacillus casei strain Shirota reduces incidence of hard or lumpy stools in healthy population ' () 62 International Journal of Food Sciences and Nutrition : 423 -430.
-
Saurel-Cubizolles, M.J., Romito, P., Lelong, N. and Ancel, P.Y., 2000. Women's health after childbirth: a longitudinal study in France and Italy. BJOG: an International Journal of Obstetrics and Gynaecology 107: 1202-1209.
'Women's health after childbirth: a longitudinal study in France and Italy ' () 107 BJOG: an International Journal of Obstetrics and Gynaecology : 1202 -1209.
-
Seymour, C.A. and Chadwick, V.S., 1979. Liver and gastrointestinal function in pregnancy. Postgraduate Medical Journal 55: 343-352.
'Liver and gastrointestinal function in pregnancy ' () 55 Postgraduate Medical Journal : 343 -352.
-
Shelton, M.G., 1980. Standardized senna in the management of constipation in the puerperium: a clinical trial. South African Medical Journal 57: 78-80.
'Standardized senna in the management of constipation in the puerperium: a clinical trial ' () 57 South African Medical Journal : 78 -80.
-
Sloots, C.E., Rykx, A., Cools, M., Kerstens, R. and De Pauw, M., 2010. Efficacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation. Diseases of the Colon and Rectum 55: 2912-2921.
'Efficacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation ' () 55 Diseases of the Colon and Rectum : 2912 -2921.
-
Tack, J., Müller-Lissner, S., Stanghellini, V., Boeckxstaens, G., Kamm, M.A., Simren, M., Galmiche, J.P. and Fried, M., 2011. Diagnosis and treatment of chronic constipation – a European perspective. Neurogastroenterology and Motility 23: 697-710.
'Diagnosis and treatment of chronic constipation – a European perspective ' () 23 Neurogastroenterology and Motility : 697 -710.
-
Tilley, L., Keppens, K., Kushiro, A., Takada, T., Sakai, T., Vaneechoutte M. and Degeest B., 2014. A probiotic fermented milk drink containing Lactobacillus casei strain Shirota improves stool consistency of subjects with hard stools. International Journal of Probiotics and Prebiotics 9: 23-30.
'A probiotic fermented milk drink containing Lactobacillus casei strain Shirota improves stool consistency of subjects with hard stools ' () 9 International Journal of Probiotics and Prebiotics : 23 -30.
-
Trottier, M., Erebara, A. and Bozzo, P., 2012. Treating constipation during pregnancy. Canadian Family Physician 58: 836-838.
'Treating constipation during pregnancy ' () 58 Canadian Family Physician : 836 -838.
-
Wanitschke, R., Goerg, K.J. and Loew, D., 2003. Differential therapy of constipation – a review. International Journal of Clinical Pharmacology and Therapeutics 41: 14-21.
'Differential therapy of constipation – a review ' () 41 International Journal of Clinical Pharmacology and Therapeutics : 14 -21.
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Effect of fermented milk containing Lactobacillus casei strain Shirota on constipation-related symptoms and haemorrhoids in women during puerperium
In: Beneficial MicrobesSearch for other papers by T. Sakai in
Current site
Google Scholar
PubMed
Search for other papers by H. Kubota in
Current site
Google Scholar
PubMed
Search for other papers by A. Gawad in
Current site
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PubMed
Search for other papers by L. Gheyle in
Current site
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PubMed
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PubMed
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PubMed
Constipation and haemorrhoids are common complaints after childbirth. The objective of this pilot study was to evaluate impact of fermented milk containing Lactobacillus casei strain Shirota (LcS) on stool consistency and frequency, constipation-related symptoms and quality of life, and incidence of haemorrhoids in women during puerperium. Forty women who had natural childbirth were randomised to group consuming either one bottle/day of fermented milk containing at least 6.5×109 cfu of LcS, or placebo, for 6 weeks after childbirth. Subjects filled in a diary on their bowel habits including number of bowel movement, stool consistency and incidence of haemorrhoids, and answered questionnaires on constipation-related symptoms (PAC-SYM) and quality of life (PAC-QOL) during the study period. The probiotic group showed the better scores on overall PAC-SYM (P=0.013), PAC-SYM subscales of abdominal symptoms (P=0.043) and rectal symptoms (P=0.031), and PAC-QOL satisfaction subscale (P=0.037) in comparison with the placebo group. In the probiotic group, two to four subjects experienced haemorrhoids during the first 3 weeks of treatment. The number decreased in week 4 and no one had haemorrhoids on most days in week 5-6. In the placebo group, on average four subjects had haemorrhoids from the beginning, and no obvious change was observed until week 6. No statistically significant effect was observed on stool consistency and frequency. The study products did not cause any adverse event in the subjects. Results of this study indicate that continuous consumption of fermented milk containing LcS might alleviate constipation-related symptoms, provide satisfactory bowel habit and result in earlier recovery from haemorrhoids in women during puerperium. Nonetheless, there are several limitations in interpretation of the results attributed to the study design, including lack of baseline data. Further study is required in order to confirm the efficacy.
| All Time | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 347 | 343 | 52 |
| Full Text Views | 10 | 5 | 0 |
| PDF Views & Downloads | 7 | 7 | 0 |