Lactobacillus fermentum UCO-979C beneficially modulates the innate immune response triggered by Helicobacter pylori infection in vitro
In: Beneficial MicrobesLaboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman 4000, Argentina.
Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai 84-0051, Japan.
Search for other papers by V. Garcia-Castillo in
Current site
Google Scholar
Search for other papers by H. Zelaya in
Current site
Google Scholar
Search for other papers by A. Ilabaca in
Current site
Google Scholar
Search for other papers by M. Espinoza-Monje in
Current site
Google Scholar
Search for other papers by R. Komatsu in
Current site
Google Scholar
Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai 84-0051, Japan.
Laboratory of Computing Science, Faculty of Exact Sciences and Technology, Tucuman University, Av. Independencia 1800, Tucuman 4000, Argentina.
Search for other papers by L. Albarracín in
Current site
Google Scholar
International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 984-0051, Japan.
Search for other papers by H. Kitazawa in
Current site
Google Scholar
Search for other papers by A. Garcia-Cancino in
Current site
Google Scholar
Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai 84-0051, Japan.
Search for other papers by J. Villena in
Current site
Google Scholar
Helicobacter pylori infection is associated with important gastric pathologies. An aggressive proinflammatory immune response is generated in the gastric tissue infected with H. pylori, resulting in gastritis and a series of morphological changes that increase the susceptibility to cancer development. Probiotics could present an alternative solution to prevent or decrease H. pylori infection. Among them, the use of immunomodulatory lactic acid bacteria represents a promising option to reduce the severity of chronic inflammatory-mediated tissue damage and to improve protective immunity against H. pylori. We previously isolated Lactobacillus fermentum UCO-979C from human gastric tissue and demonstrated its capacity to reduce adhesion of H. pylori to human gastric epithelial cells (AGS cells). In this work, the ability of L. fermentum UCO-979C to modulate immune response in AGS cells and PMA phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 (human monocytic leukaemia) macrophages in response to H. pylori infection was evaluated. We demonstrated that the UCO-979C strain is able to differentially modulate the cytokine response of gastric epithelial cells and macrophages after H. pylori infection. Of note, L. fermentum UCO-979C was able to significantly reduce the production of inflammatory cytokines and chemokines in AGS and THP-1 cells as well as increase the levels of immunoregulatory cytokines, indicating a remarkable anti-inflammatory effect. These findings strongly support the probiotic potential of L. fermentum UCO-979C and provide evidence of its beneficial effects against the inflammatory damage induced by H. pylori infection. Although our findings should be proven in appropriate experiments in vivo, in both H. pylori infection animal models and human trials, the results of the present work provide a scientific rationale for the use of L. fermentum UCO-979C to prevent or reduce H. pylori-induced gastric inflammation in humans.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Ansari, S.A., Devi, S., Tenguria, S., Kumar, A. and Ahmed, N., 2014. Helicobacter pylori protein HP0986 (TieA) interacts with mouse TNFR1 and triggers proinflammatory and proapoptotic signaling pathways in cultured macrophage cells (RAW 264.7). Cytokine 68: 110-117.
'Helicobacter pylori protein HP0986 (TieA) interacts with mouse TNFR1 and triggers proinflammatory and proapoptotic signaling pathways in cultured macrophage cells (RAW 264.7) ' () 68 Cytokine : 110 -117 .
-
Bamford, K.B., Fan, X., Crowe, S.E., Leary, J.F., Gourley, W.K., Luthra, G.K., Brooks, E.G. Graham, D.Y., Reyes, V.E. and Ernst, P.B., 1998. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology 114: 482-492.
'Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype ' () 114 Gastroenterology : 482 -492 .
-
Bimczok, D., Smythies, L.E., Waites, K.B., Grams, J.M., Stahl, R.D., Mannon, P.J., Peter, S., Wilcox, C.M., Harris, P.R., Das, S., Ernst, P.B. and Smith, P.D., 2013. Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells. Journal of Immunology 190: 6626-6634.
'Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells ' () 190 Journal of Immunology : 6626 -6634 .
-
Brandt, S., Kwok, T., Hartig, R., König, W. and Backert, S., 2005. NF-kB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proceedings of the National Academy of Sciences of the USA 102: 9300-9305.
'NF-kB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein ' () 102 Proceedings of the National Academy of Sciences of the USA : 9300 -9305 .
-
Carron, M.A., Tran, T.R., Sugawa, C. and Coticchia, J.M., 2006. Identification of Helicobacter pylori biofilms in human gastric mucosa. Journal of Gastrointestinal Surgery 10: 712-717.
'Identification of Helicobacter pylori biofilms in human gastric mucosa ' () 10 Journal of Gastrointestinal Surgery : 712 -717 .
-
Crabtree, J.E., Wyatt, J.I., Trejdosiewicz, L.K., Peichl, P., Nichols, P.H., Ramsay, N., Primrose, J.N. and Lindley, I.J., 1994. Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa. Journal of Clinical Pathology 47: 61-66.
'Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa ' () 47 Journal of Clinical Pathology : 61 -66 .
-
D’Elios, M.M., Manghetti, M., De Carli, M., Costa, F., Baldari, C.T., Burroni, D., Telford, J.L., Romagnani, S. and Del Prete, G., 1997. T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. Journal of Immunology 158: 962-967.
'T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease ' () 158 Journal of Immunology : 962 -967 .
-
Doger, F.K., Meteoglu, I., Ozkara, E., Erkul, Z.K., Okyay, P. and Yukselen, V., 2006. Expression of NFkappaB in Helicobacter pylori infection. Digestive Diseases and Sciences 51: 2306-2309.
'Expression of NFkappaB in Helicobacter pylori infection ' () 51 Digestive Diseases and Sciences : 2306 -2309 .
-
Eftang, L.L., Esbensen, Y., Tannaes, T.M., Bukholm, I.R. and Bukholm, G., 2012. Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells. BMC Microbiology 12: 9.
'Interleukin-8 is the single most up-regulated gene in whole genome profiling of H ' () 12 BMC Microbiology : 9 .
-
Fan, X.G., Chua, A., Fan, X.J. and Keeling, P.W., 1995. Increased gastric production of interleukin-8 and tumour necrosis factor in patients with Helicobacter pylori infection. Journal of Clinical Pathology 48: 133-136.
'Increased gastric production of interleukin-8 and tumour necrosis factor in patients with Helicobacter pylori infection ' () 48 Journal of Clinical Pathology : 133 -136 .
-
Fehlings, M., Drobbe, L., Moos, V., Viveros, P.R., Hagen, J., Beigier-Bompadre, M., Pang, E., Belogolova, E., Churin, Y., Schneider, T., Meyer, T.F., Aebischer, T. and Ignatius, R., 2012. Comparative analysis of the interaction of Helicobacter pylori with human dendritic cells, macrophages, and monocytes. Infection and Immunity 80: 2724-2734.
'Comparative analysis of the interaction of Helicobacter pylori with human dendritic cells, macrophages, and monocytes ' () 80 Infection and Immunity : 2724 -2734 .
-
Garcia, A., Henriquez, A.P., Retamal, R.C., Pineda, C.S., Delgado, C. and Gonzalez, C.C., 2009. Probiotic properties of Lactobacillus spp. isolated from gastric biopsies of Helicobacter pylori infected and non-infected individuals. Revista Médica de Chile 137: 369-376.
'Probiotic properties of Lactobacillus spp. isolated from gastric biopsies of Helicobacter pylori infected and non-infected individuals ' () 137 Revista Médica de Chile : 369 -376 .
-
García, A., Navarro, K., Sanhueza, E., Pineda, S., Pastene, E., Quezada, M., Henríquez, K., Karlyshev, A., Villena, J. and González, C., 2017. Characterization of Lactobacillus fermentum UCO-979C, a probiotic strain with a potent anti-Helicobacter pylori activity. Electronic Journal of Biotechnology 25: 75-83.
'Characterization of Lactobacillus fermentum UCO-979C, a probiotic strain with a potent anti-Helicobacter pylori activity ' () 25 Electronic Journal of Biotechnology : 75 -83 .
-
García, A., Salas-Jara, M.J., Herrera, C. and González, C., 2014. Biofilm and Helicobacter pylori: from environment to human host. World Journal of Gastroenterology 20: 5632-5638.
'Biofilm and Helicobacter pylori: from environment to human host ' () 20 World Journal of Gastroenterology : 5632 -5638 .
-
Goderska, K., Agudo Pena, S. and Alarcon, T., 2018. Helicobacter pylori treatment: antibiotics or probiotics. Applied Microbiology and Biotechnology 102: 1-7.
'Helicobacter pylori treatment: antibiotics or probiotics ' () 102 Applied Microbiology and Biotechnology : 1 -7 .
-
Hahm, K.B., Lee, K.M., Kim, Y.B., Hong, W.S., Lee, W.H., Han, S.U., Kim, M.W., Ahn, B.O., Oh, T.Y., Lee, M.H., Green, J. and Kim, S.J., 2002. Conditional loss of TGF-β signaling leads to increased susceptibility to gastrointestinal carcinogenesis in mice. Alimentary Pharmacology & Therapeutics 16: 115-127.
'Conditional loss of TGF-β signaling leads to increased susceptibility to gastrointestinal carcinogenesis in mice ' () 16 Alimentary Pharmacology & Therapeutics : 115 -127 .
-
Hauser, G., Salkic, N., Vukelic, K., JajacKnez, A. and Stimac, D., 2015. Probiotics for standard triple Helicobacter pylori eradication: a randomized, double-blind, placebo-controlled trial. Medicine 94: e685.
'Probiotics for standard triple Helicobacter pylori eradication: a randomized, double-blind, placebo-controlled trial ' () 94 Medicine : e685 .
-
Homan, M. and Orel, R., 2015. Are probiotics useful in Helicobacter pylori eradication? World Journal of Gastroenterology 21: 10644-10653.
'Are probiotics useful in Helicobacter pylori eradication? ' () 21 World Journal of Gastroenterology : 10644 -10653 .
-
Kameoka, S., Kameyama, T., Hayashi, T., Sato, S., Ohnishi, N., Hayashi, T., Murata-Kamiya, N., Higashi, H., Hatakeyama, M. and Takaoka, A., 2016. Helicobacter pylori induces IL-1β protein through the inflammasome activation in differentiated macrophagic cells. Biomedical Research 37: 21-27.
'Helicobacter pylori induces IL-1β protein through the inflammasome activation in differentiated macrophagic cells ' () 37 Biomedical Research : 21 -27 .
-
Marcial, G., Villena, J., Faller, G., Hensel, A. and De Valdéz, G.F., 2017. Exopolysaccharide-producing Streptococcus thermophilus CRL1190 reduces the inflammatory response caused by Helicobacter pylori. Beneficial Microbes 8: 451-461.
'Exopolysaccharide-producing Streptococcus thermophilus CRL1190 reduces the inflammatory response caused by Helicobacter pylori ' () 8 Beneficial Microbes : 451 -461 .
-
Monteleone, G., Del Vecchio Blanco, G., Palmieri, G., Vavassori, P., Monteleone, I., Colantoni, A., Battista, S., Spagnoli, L.G., Romano, M., Borrelli, M., MacDonald, T.T. and Pallone, F., 2004a. Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection. Gastroenterology 126: 674-682.
'Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection ' () 126 Gastroenterology : 674 -682 .
-
Monteleone, G., Pallone, F. and MacDonald, T.T., 2004b. Smad7 in TGF-beta-mediated negative regulation of gut inflammation. Trends in Immunology 25: 513-517.
'Smad7 in TGF-beta-mediated negative regulation of gut inflammation ' () 25 Trends in Immunology : 513 -517 .
-
Muller, A. and Solnick, J.V., 2011. Inflammation, immunity, and vaccine development for Helicobacter pylori. Helicobacter 16: 26-32.
'Inflammation, immunity, and vaccine development for Helicobacter pylori ' () 16 Helicobacter : 26 -32 .
-
Peek Jr., R.M., Fiske, C. and Wilson, K.T., 2010. Role of innate immunity in Helicobacter pylori-induced gastric malignancy. Physiological Reviews 90: 831-858.
'Role of innate immunity in Helicobacter pylori-induced gastric malignancy ' () 90 Physiological Reviews : 831 -858 .
-
Posselt, G., Backert, S. and Wessler, S., 2013. The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Communication and Signaling 11: 77.
'The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis ' () 11 Cell Communication and Signaling : 77 .
-
Salas-Jara, M.J., Sanhueza, E.A., Retamal-Díaz, A., González, C., Urrutia, H. and García, A., 2016. Probiotic Lactobacillus fermentum UCO-979C biofilm formation on AGS and Caco-2 cells and Helicobacter pylori inhibition. Biofouling 32: 1245-1257.
'Probiotic Lactobacillus fermentum UCO-979C biofilm formation on AGS and Caco-2 cells and Helicobacter pylori inhibition ' () 32 Biofouling : 1245 -1257 .
-
Serrano, C., Diaz, M.I., Valdivia, A., Godoy, A., Peña, A., Rollan, A., Kirberg, A., Hebel, E., Fierro, J., Klapp, G., Venegas, A. and Harris, P.R., 2007. Relationship between Helicobacter pylori virulence factors and regulatory cytokines as predictors of clinical outcome. Microbes and Infection 9: 428-434.
'Relationship between Helicobacter pylori virulence factors and regulatory cytokines as predictors of clinical outcome ' () 9 Microbes and Infection : 428 -434 .
-
Shimazu, T., Villena, J., Tohno, M., Fujie, H., Hosoya, S., Shimosato, T., Aso, H., Suda, Y., Kawai, Y., Saito, T., Makino, S., Ikegami, S., Itoh, H. and Kitazawa, H., 2012. Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway. Infection and Immunity 80: 276.
'Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway ' () 80 Infection and Immunity : 276 .
-
Straubinger, R.K., Greiter, A., McDonough, S.P., Gerold, A., Scanziani, E., Soldati, S., Dailidiene, D., Dailide, G., Berg, D.E. and Simpson, K.W., 2003. Quantitative evaluation of inflammatory and immune responses in the early stages of chronic Helicobacter pylori infection. Infection and Immunity 71: 2693-2703.
'Quantitative evaluation of inflammatory and immune responses in the early stages of chronic Helicobacter pylori infection ' () 71 Infection and Immunity : 2693 -2703 .
-
Suzuki, H., Mori, M., Sakaguchi, A.A., Suzuki, M., Miura, S. and Ishii, H., 1998. Enhanced levels of C-X-C chemokine, human GROalpha, in Helicobacter pylori-associated gastric disease. Journal of Gastroenterology and Hepatology 13: 516-520.
'Enhanced levels of C-X-C chemokine, human GROalpha, in Helicobacter pylori-associated gastric disease ' () 13 Journal of Gastroenterology and Hepatology : 516 -520 .
-
Terraf, M.C., Juarez Tomas, M.S., Nader-Macias, M.E. and Silva, C., 2012. Screening of biofilm formation by beneficial vaginal lactobacilli and influence of culture media components. Journal of Applied Microbiology 113: 1517-1529.
'Screening of biofilm formation by beneficial vaginal lactobacilli and influence of culture media components ' () 113 Journal of Applied Microbiology : 1517 -1529 .
-
Thiraworawong, T., Spinler, J.K., Werawatganon, D., Klaikeaw, N., Venable, S.F., Versalovic, J. and Tumwasorn, S., 2014. Anti-inflammatory properties of gastric-derived Lactobacillus plantarum XB7 in the context of Helicobacter pylori infection. Helicobacter 19: 144-155.
'Anti-inflammatory properties of gastric-derived Lactobacillus plantarum XB7 in the context of Helicobacter pylori infection ' () 19 Helicobacter : 144 -155 .
-
Ushiyama, A., Tanaka, K., Aiba, Y., Shiba, T., Takagi, A., Mine, T. and Koga, Y., 2003. Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection. Journal of Gastroenterology and Hepatology 18: 986-991.
'Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection ' () 18 Journal of Gastroenterology and Hepatology : 986 -991 .
-
Viladomiu, M., Bassaganya-Riera, J., Tubau-Juni, N., Kronsteiner, B., Leber, A., Philipson, C.W., Zoccoli-Rodriguez, V. and Hontecillas, R., 2017. Cooperation of gastric mononuclear phagocytes with Helicobacter pylori during colonization. Journal of Immunology 198: 3195-3204.
'Cooperation of gastric mononuclear phagocytes with Helicobacter pylori during colonization ' () 198 Journal of Immunology : 3195 -3204 .
-
Wang, F., Mao, Z., Liu, D., Yu, J., Wang, Y., Ye, W., Lin, D., Zhou, N. and Xie, Y., 2017. Overexpression of Tim-3 reduces Helicobacter pylori-associated inflammation through TLR4/NFκB signaling in vitro. Molecular Medicine Reports 15: 3252-3258.
'Overexpression of Tim-3 reduces Helicobacter pylori-associated inflammation through TLR4/NFκB signaling in vitro ' () 15 Molecular Medicine Reports : 3252 -3258 .
-
Xuan, J., Deguchi, R., Yanagi, H., Ozawa, H., Urano, T., Ogawa, Y., Fukuda, R., Kojima, S., Nishina, M., Sudo, H., Kijima, H., Koga, Y. and Takagi, A., 2005. Relationship between gastric mucosal IL-8 levels and histological gastritis in patients with Helicobacter pylori infection. Tokai Journal of Experimental and Clinical Medicine 30: 83-88.
'Relationship between gastric mucosal IL-8 levels and histological gastritis in patients with Helicobacter pylori infection ' () 30 Tokai Journal of Experimental and Clinical Medicine : 83 -88 .
-
Yamada, S., Kato, S., Matsuhisa, T., Makonkawkeyoon, L., Yoshida, M., Chakrabandhu, T., Lertprasertsuk, N., Suttharat, P., Chakrabandhu, B., Nishiumi, S., Chongraksut, W. and Azuma, T., 2013. Predominant mucosal IL-8 mRNA expression in non-cagA Thais is risk for gastric cancer. World Journal of Gastroenterology 19: 2941-2949.
'Predominant mucosal IL-8 mRNA expression in non-cagA Thais is risk for gastric cancer ' () 19 World Journal of Gastroenterology : 2941 -2949 .
-
Yang, Y.J., Chuang, C.C., Yang, H.B., Lu, C.C. and Sheu, B.S., 2012. Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFκB pathways. BMC Microbiology 12: 38.
'Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFκB pathways ' () 12 BMC Microbiology : 38 .
-
Zhang, Y., Sun, H., Li, J., Rong, Q., Ji, X. and Li, B., 2017. The leukocyte-associated immunoglobulin (Ig)-like receptor-1 modulating cell apoptosis and inflammatory cytokines secretion in THP-1 cells after Helicobacter pylori infection. Microbial Pathogenesis 109: 292-299.
'The leukocyte-associated immunoglobulin (Ig)-like receptor-1 modulating cell apoptosis and inflammatory cytokines secretion in THP-1 cells after Helicobacter pylori infection ' () 109 Microbial Pathogenesis : 292 -299 .
| All Time | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 18 | 18 | 1 |
| Full Text Views | 4 | 4 | 0 |
| PDF Views & Downloads | 3 | 3 | 0 |
Lactobacillus fermentum UCO-979C beneficially modulates the innate immune response triggered by Helicobacter pylori infection in vitro
In: Beneficial MicrobesLaboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman 4000, Argentina.
Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai 84-0051, Japan.
Search for other papers by V. Garcia-Castillo in
Current site
Google Scholar
PubMed
Search for other papers by H. Zelaya in
Current site
Google Scholar
PubMed
Search for other papers by A. Ilabaca in
Current site
Google Scholar
PubMed
Search for other papers by M. Espinoza-Monje in
Current site
Google Scholar
PubMed
Search for other papers by R. Komatsu in
Current site
Google Scholar
PubMed
Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai 84-0051, Japan.
Laboratory of Computing Science, Faculty of Exact Sciences and Technology, Tucuman University, Av. Independencia 1800, Tucuman 4000, Argentina.
Search for other papers by L. Albarracín in
Current site
Google Scholar
PubMed
International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 984-0051, Japan.
Search for other papers by H. Kitazawa in
Current site
Google Scholar
PubMed
Search for other papers by A. Garcia-Cancino in
Current site
Google Scholar
PubMed
Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai 84-0051, Japan.
Search for other papers by J. Villena in
Current site
Google Scholar
PubMed
Helicobacter pylori infection is associated with important gastric pathologies. An aggressive proinflammatory immune response is generated in the gastric tissue infected with H. pylori, resulting in gastritis and a series of morphological changes that increase the susceptibility to cancer development. Probiotics could present an alternative solution to prevent or decrease H. pylori infection. Among them, the use of immunomodulatory lactic acid bacteria represents a promising option to reduce the severity of chronic inflammatory-mediated tissue damage and to improve protective immunity against H. pylori. We previously isolated Lactobacillus fermentum UCO-979C from human gastric tissue and demonstrated its capacity to reduce adhesion of H. pylori to human gastric epithelial cells (AGS cells). In this work, the ability of L. fermentum UCO-979C to modulate immune response in AGS cells and PMA phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 (human monocytic leukaemia) macrophages in response to H. pylori infection was evaluated. We demonstrated that the UCO-979C strain is able to differentially modulate the cytokine response of gastric epithelial cells and macrophages after H. pylori infection. Of note, L. fermentum UCO-979C was able to significantly reduce the production of inflammatory cytokines and chemokines in AGS and THP-1 cells as well as increase the levels of immunoregulatory cytokines, indicating a remarkable anti-inflammatory effect. These findings strongly support the probiotic potential of L. fermentum UCO-979C and provide evidence of its beneficial effects against the inflammatory damage induced by H. pylori infection. Although our findings should be proven in appropriate experiments in vivo, in both H. pylori infection animal models and human trials, the results of the present work provide a scientific rationale for the use of L. fermentum UCO-979C to prevent or reduce H. pylori-induced gastric inflammation in humans.
| All Time | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 18 | 18 | 1 |
| Full Text Views | 4 | 4 | 0 |
| PDF Views & Downloads | 3 | 3 | 0 |