Short-term stall housing of horses results in changes of markers of bone metabolism
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In previous research, stall-housing growing horses resulted in decreased bone mineral content (BMC) of the third metacarpal (MCIII) compared to pasture-housing. To determine whether stall confinement negatively impacts bone, regardless of age, and whether the effects could be reversed upon return to pasture, 12 mature horses (5-15 years) and 12 yearlings were pair-matched by age and gender and randomly assigned to one of two treatment groups: pasture (PT) or stall (ST). Horses on PT remained there for the 84-d study, while horses on ST spent the first 28 d in stalls and the remaining 56 d on pasture. Radiographs and blood samples were taken on d 0 for baseline determinants. Radiographs and blood were taken every 7 d for radiographic photodensitometry estimates of BMC and analysis of osteocalcin (OC) and C-telopeptide (CTX-1)-markers of bone formation and degradation. There were no differences in BMC between treatments at the medial cortex of MCIII in mature horses. There were treatment (P=0.05) and day (P<0.01) differences in BMC at the lateral cortex of MCIII. In yearling horses, the BMC of the medial cortex of MCIII had a day difference with the lowest overall average at d 21 and highest at d 70 (P=0.04). There were day by treatment differences (P<0.05) for both OC and CTX-1 with the mature and yearling horses on ST having lower OC on d 14 than PT horses (P<0.05) indicative of reduced bone formation. In mature and yearling ST horses, CTX-1 was greater on d 14 and 28 compared to horses on PT (P≤0.05) suggesting greater bone resorption. Results from serum markers of bone formation and deformation confirm that stalling negatively impacts bone formation in horses regardless of age.
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Allen, M.R. and Burr, D.B., 2014. Bone modeling and remodeling. In: Burr, D.B. and Allen, M.R. (eds.) Basic and applied bone biology. Academic Press, San Diego, CA, USA, pp. 75-90. https://doi.org/10.1016/B978-0-12-416015-6.00004-6
-
Bell, R.A., Nielsen, B.D., Waite, K., Rosenstein, D. and Orth., M., 2001. Daily access to pasture turnout prevents loss of mineral in the third metacarpus of Arabian weanlings. Journal of Animal Science 79: 1142-1150. https://doi.org/10.2527/2001.7951142x
-
Billinghurst, R., 2003. Significant exercise-related changes in the serum levels of two biomarkers of collagen metabolism in young horses. Osteoarthritis and Cartilage 11(10): 760-769. https://doi.org/10.1016/S1063-4584(03)00152-3
-
Christensen, J.W., Søndergaard, E., Thodberg, K. and Halekoh, U., 2011. Effects of repeated regrouping on horse behaviour and injuries. Applied Animal Behaviour Science 133(3-4): 199-206. https://doi.org/10.1016/j.applanim.2011.05.013
-
Cohen, N.D., Berry, S.M., Peloso, J.G., Mundy, G.D. and Howard, I.C. 2000. Association of high speed exercise with racing injury in Thoroughbreds. Journal of the American Veterinary Medical Association 216(8): 1273-1278. https://doi.org/10.2460/javma.2000.216.1273
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Emmert, B.J., Robison, C.I., Pritchard, A. and Nielsen, B.D., 2019. Comparison of total radiographic bone aluminum equivalences (RBAE) from digital radiographs to bone ash content of the equine third metacarpal. Journal of Equine Veterinary Science. 76: 128. https://doi.org/10.1016/j.jevs.2019.03.205
-
Henneke, D.R., Potter, G.D., Kreider, J.L. and Yeates, B.F., 1983. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Veterinary Journal 15: 371-372. https://doi.org/10.1111/j.2042-3306.1983.tb01826.x
-
Hiney, K.M., Nielsen, B.D. and Rosenstein, D.S., 2004b. Short-duration exercise and confinement alters bone mineral content and shape in weanling horses. Journal of Animal Science 82(8): 2313-2320. https://doi.org/10.2527/2004.8282313x
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Hiney, K.M., Nielsen, B.D., Orth, M.W., Rosenstein, D.S. and Marks, B.P., 2004a. Short duration, high intensity exercise alters bovine bone density and shape. Journal of Animal Science 82(6): 1612-1620. https://doi.org/10.2527/2004.8261612x
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Hoekstra, K.E., Nielsen, B.D., Orth, M.W., Rosenstein, D.S., Schott, H.C. and Shelle, J.E., 1999. Comparison of bone mineral content and bone metabolism in stall-versus pasture-reared horses. Equine Veterinary Journal 30: 601-604. https://doi.org/10.1111/j.2042-3306.1999.tb05292.x
-
Inman, C.L., Warren, G.L., Hogan, H.A. and Bloomfield, S.A., 1999. Mechanical loading attenuates bone loss due to immobilization and calcium deficiency. Journal of Applied Physiology 87(1): 189-195. https://doi.org/10.1152/jappl.1999.87.1.189
-
Lang, K.J., Nielsen, B.D. and Orth, M.W., 2002. Bone metabolism markers in Arabian horses during the first two years of life. The Professional Animal Scientist 18(2): 180-183. https://doi.org/10.15232/S1080-7446(15)31509-6
-
Lepage, O.M., Marcoux, M. and Tremblay, A., 1990. Serum osteocalcin or bone gla-protein, a biochemical marker for bone metabolism in horses: differences in serum levels with age. Canadian Journal of Veterinary Research 54: 223-226.
'Serum osteocalcin or bone gla-protein, a biochemical marker for bone metabolism in horses: differences in serum levels with age ' () 54 Canadian Journal of Veterinary Research : 223 -226 .
-
Logan, A. A., Nielsen B.D., Robison, C.I., Manfredi, J.M., Buskirk, D.D., Schott, H.C. and Hiney, K.M., 2019. Calves, as a model for juvenile horses, need only one sprint per week to experience increased bone strength. Journal of Animal Science 97: 3300-3312. https://doi.org/10.1093/jas/skz202
-
Meakim, D.W., Ott, E.A., Asquith, R.L. and Feaster, J.P., 1981. Estimation of mineral content of the equine third metacarpal by radiographic photometry. Journal of Animal Science 53: 1019-1026. https://doi.org/10.2527/jas1981.5341019x
-
Nielsen, B.D. and Spooner, H.S., 2008. Small changes in exercise, not nutrition, often result in measurable changes in bone. Comparative Exercise Physiology 5(1): 15-20. https://doi.org/10.1017/s1478061508914493
-
Nielsen, B.D., Potter, G.D., Morris, E.L., Odom, T.W., Senor, D.M., Reynolds, J.A., Smith, W.B. and Martin, M.T., 1997. Changes in the third metacarpal bone and frequency of bone injuries in young Quarter Horses during race training – observations and theoretical considerations. Journal of Equine Veterinary Science 17(10): 541-549. https://doi.org/10.1016/S0737-0806(97)80227-4
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Pagan, J.D., Kazakevicius, P., Swanhall, A., Ford, E. and Pritchard, A., 2017. Comparison of processed and unprocessed digital images for the determination of radiographic bone aluminum equivalent (RBAE) values in equine bone. Journal of Equine Veterinary Science 52: 54-55. https://doi.org/10.1016/j.jevs.2017.03.046
-
Porr, C.A., Kronfeld, D.S., Lawrence, L.A., Pleasant, R.S. and Harris, P.A., 1998. Deconditioning reduces mineral content of the third metacarpal bone in horses. Journal of Animal Science 76: 1875-1879. https://doi.org/10.2527/1998.7671875x
-
Robison, C.I. and Nielsen, B.D., 2013. Comparison of two software packages for determining radiographic bone aluminum equivalent values. Comparative Exercise Physiology 9(3-4): 219-222. https://doi.org/10.3920/CEP13024
-
Rubin, C.T. and Lanyon, L.E., 1984. Regulation of bone formation by applied dynamic loads. Journal of Bone and Joint Surgery 66: 397-402.
'Regulation of bone formation by applied dynamic loads ' () 66 Journal of Bone and Joint Surgery : 397 -402 .
-
Skerry, T.M., 2008. The response of bone to mechanical loading and disuse: fundamental principles and influences on osteoblast/osteocyte homeostasis. Archives of Biochemistry and Biophysics 473: 117-123. https://doi.org/10.1016/j.abb.2008.02.028
-
Smith, R.K. and Goodship, A.E., 2008. The effect of early training and the adaptation and conditioning of skeletal tissues. Veterinary Clinics of North American-Equine Practice 24: 37-51. https://doi.org/10.1016/j.cveq.2007.11.005
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Spooner, H.S., Nielsen, B.D., Woodward, A.D., Rosenstein, D.S. and Harris, P.A., 2008. Endurance training has little impact on mineral content of the third metacarpus in two-year-old Arabian horses. Journal of Equine Veterinary Science 28: 359-362. https://doi.org/10.1016/j.jevs.2008.04.012
| All Time | Past 365 days | Past 30 Days | |
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Short-term stall housing of horses results in changes of markers of bone metabolism
In: Comparative Exercise PhysiologySearch for other papers by A.A. Logan in
Current site
Google Scholar
PubMed
Search for other papers by B.D. Nielsen in
Current site
Google Scholar
PubMed
Search for other papers by R. Sehl in
Current site
Google Scholar
PubMed
Search for other papers by E. Jones in
Current site
Google Scholar
PubMed
Search for other papers by C.I. Robison in
Current site
Google Scholar
PubMed
Search for other papers by A.P. Pease in
Current site
Google Scholar
PubMed
In previous research, stall-housing growing horses resulted in decreased bone mineral content (BMC) of the third metacarpal (MCIII) compared to pasture-housing. To determine whether stall confinement negatively impacts bone, regardless of age, and whether the effects could be reversed upon return to pasture, 12 mature horses (5-15 years) and 12 yearlings were pair-matched by age and gender and randomly assigned to one of two treatment groups: pasture (PT) or stall (ST). Horses on PT remained there for the 84-d study, while horses on ST spent the first 28 d in stalls and the remaining 56 d on pasture. Radiographs and blood samples were taken on d 0 for baseline determinants. Radiographs and blood were taken every 7 d for radiographic photodensitometry estimates of BMC and analysis of osteocalcin (OC) and C-telopeptide (CTX-1)-markers of bone formation and degradation. There were no differences in BMC between treatments at the medial cortex of MCIII in mature horses. There were treatment (P=0.05) and day (P<0.01) differences in BMC at the lateral cortex of MCIII. In yearling horses, the BMC of the medial cortex of MCIII had a day difference with the lowest overall average at d 21 and highest at d 70 (P=0.04). There were day by treatment differences (P<0.05) for both OC and CTX-1 with the mature and yearling horses on ST having lower OC on d 14 than PT horses (P<0.05) indicative of reduced bone formation. In mature and yearling ST horses, CTX-1 was greater on d 14 and 28 compared to horses on PT (P≤0.05) suggesting greater bone resorption. Results from serum markers of bone formation and deformation confirm that stalling negatively impacts bone formation in horses regardless of age.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 170 | 108 | 12 |
| Full Text Views | 14 | 2 | 0 |
| PDF Views & Downloads | 16 | 4 | 0 |
