Effect of lactate administration on exercise-induced PGC-1α mRNA expression in Thoroughbreds
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The aim of this study was to examine the effects of lactate administration on the mRNA response of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) to acute exercise in Thoroughbred skeletal muscle. Five Thoroughbred horses performed treadmill running at 90% of maximal oxygen consumption for 2 min on two separate occasions, either after the administration of two litres of a sodium lactate solution (LAC; 500 mmol/l sodium lactate in 0.9% NaCl) or a saline solution as a control (CON; 0.9% NaCl). Lactate administration significantly elevated the peak plasma lactate concentration during exercise (16.0±2.8 mmol/l in LAC vs 10.8±2.2 mmol/l in CON). The increase in PGC-1α mRNA expression after 4 h of recovery from exercise was similar between treatments. However, there was positive correlation between exercise-induced PGC-1α mRNA response at 4 h after exercise and peak plasma lactate concentration during exercise. These results suggest that the exercise intensity-dependent adaptation of PGC-1α may be attributed, at least in part, to an increased lactate concentration.
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'Peroxisomal proliferator-activated receptor gamma co-activator-1 alpha gene expression increases above the lactate threshold in human skeletal muscle ' () 51 Journal of Sports Medicine and Physical Fitness : 683 -688 .
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Effect of lactate administration on exercise-induced PGC-1α mRNA expression in Thoroughbreds
In: Comparative Exercise PhysiologySearch for other papers by Y. Kitaoka in
Current site
Google Scholar
PubMed
Search for other papers by K. Mukai in
Current site
Google Scholar
PubMed
Search for other papers by K. Takahashi in
Current site
Google Scholar
PubMed
Search for other papers by H. Ohmura in
Current site
Google Scholar
PubMed
Search for other papers by H. Hatta in
Current site
Google Scholar
PubMed
The aim of this study was to examine the effects of lactate administration on the mRNA response of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) to acute exercise in Thoroughbred skeletal muscle. Five Thoroughbred horses performed treadmill running at 90% of maximal oxygen consumption for 2 min on two separate occasions, either after the administration of two litres of a sodium lactate solution (LAC; 500 mmol/l sodium lactate in 0.9% NaCl) or a saline solution as a control (CON; 0.9% NaCl). Lactate administration significantly elevated the peak plasma lactate concentration during exercise (16.0±2.8 mmol/l in LAC vs 10.8±2.2 mmol/l in CON). The increase in PGC-1α mRNA expression after 4 h of recovery from exercise was similar between treatments. However, there was positive correlation between exercise-induced PGC-1α mRNA response at 4 h after exercise and peak plasma lactate concentration during exercise. These results suggest that the exercise intensity-dependent adaptation of PGC-1α may be attributed, at least in part, to an increased lactate concentration.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 211 | 122 | 5 |
| Full Text Views | 13 | 2 | 1 |
| PDF Views & Downloads | 19 | 3 | 0 |
