Despite ebbs and flows in comparative regional studies over the past few decades, the regional dimension of world politics is gaining sustained attention from scholarly and policymaking communities. Thus far much of the focus has been on regional integration, which is traditionally viewed as a necessary condition for economic development and security provision. This article describes the problem of regional fracture in conflict regions; it delineates the political and economic dimensions of regional fracture; and examines the security implications of each. It examines the problem of fractured regions in Russia’s post-Soviet neighborhoods, the Balkans, and sub-Saharan Africa. The article concludes with implications for security policy as exercised by the West in the post-American world.