The authors argue in this article that the main dimensions to be considered regarding the implementation of the Responsibility to Protect in Latin America and the Caribbean are the preventive dimension and, eventually the rebuilding dimension. The preventive dimension of the Responsibility to Protect cannot be dissociated from a general strategy of armed or violent conflict prevention, and should not be focused only in the prevention of mass atrocities. In the framework of the juridical and cultural legacy of the region, special attention should be directed to avoid considering the reactive dimension of RtoP, as well-embedded principles of national sovereignty, non-intervention and regional peaceful resolution of disputes obstruct any attempt of external intervention, even if they are related to international community initiatives. In this regard, the authors argue that the traditional role of regional organisations and mechanisms in peaceful resolution of inter-state conflicts, should be deepened, combined and coordinated with civil society initiatives, in the implementation of RtoP. The role of civil society organisations and networks should be strengthened through an increasing capacity building process, which includes developing skills and capacities to address both prevention and early warning, and which ought to be based on research, education and networking.