Due to the ineffectiveness of the extant regulatory framework (not limited to home country, host country and international law) governing the activities of multinational corporations (mncs), new regulatory paradigms have been advocated by scholars. Arguably, the African Union (au) (and its mechanisms) can be the basis of mnc regulation in Africa. However, regulation of the activities of mncs operating in Africa appears not to be among the major or pressing priorities of the au and its institutions. There is no normative and institutional framework at the au level regulating the activities of mncs in Africa. There are, however, moves to design measures to redress this anomaly. This article will focus on the development of recent strategies by the au and its institutions to ‘regulate’ the activities of mncs in Africa and its implications in Nigeria.