The practice of international mediation is widely recognized as essential for international peace and security, and its advantages have been extensively acknowledged. It is also an integral component of international negotiation and the peaceful settlement of disputes. Nevertheless, most of the governmental and non-governmental actors involved in international mediation processes come from predominantly Northern countries. Very few states and civil society institutions from the Global South are engaged in international mediation initiatives or have invested in improving their national mediation capacities. Looking into the future, the involvement of the South in these efforts is needed more than ever. World leaders, from the North and the Global South need to revitalize principled commitments and allow great negotiators to come to the fore to reverse deadlocked and perilous situations in the search for peace and prosperity.