Hydropolitics is a relatively new addition to the field of international security and negotiation studies. This article analyzes water, conflict and cooperation in general terms and then examines the case studies presented in this issue within the context of international relations and negotiation studies. In so doing, the article offers a framework in which to consider hydropolitics. This framework supports a process-oriented approach that emphasizes the international context, the regional context and its politics, pertinent intervening variables and the interactions among the parties within their respective negotiations. It demonstrates the necessity of such an integrated approach when analyzing hydropolitical relations among states.