The monophyly of the following anthomyiid aggregates is substantiated: The Myopininae/ Myopinini = (Enneastigma Stein + Calythea Schnabl & Dziedzicki) + (Pegoplata Schnabl & Dziedzicki + Myopina Robineau-Desvoidy). The Afrotropical species tarsata (Adams), ornata (Bezzi) and two Oriental species, fulva (Malloch), henanensis (Ge & Fan), all currently recognized in Nupedia Karl, are either referable to Enneastigma or to a new genus in the Enneastigma + Calythea lineage. The recent inclusion of Nupedia in Pegoplata is accepted, but it is pointed out that Pegoplata s. lat. is probably paraphyletic in terms of Myopina. The monophyly of Pegoplata (section cuticornis) is confirmed, and it is argued that its sister group is section acutipennis. Section cuticornis is found to include 1 Holarctic, 2 Nearctic, and 6-7 Palearctic species of which 4 new ones are described from the Mediterranean: P. granadensis sp. n. from Sierra Nevada in Spain, and P. freidbergi sp. n., P. grandis sp. n. and P. hermonensis sp. n. from Mt. Hermon at the Lebanese/Syrian border. The Mediterranean species, which are shown to constitute a monophyletic group, are keyed and subjected to cladistic and biogeographic analyses.