Monolepta frontalis Chevrolat, 1837, a species described from the Cape of Good Hope, shows strong differences in external and genitalic characters from M. bioculata (Fabricius, 1781), type species of Monolepta Chevrolat, 1837. Herein, M. frontalis Chevrolat, 1837 is transferred to Afromaculepta gen. n., and designated as type species. Monolepta octomaculata Jacoby, 1895, and M. decemmaculata Jacoby, 1886 are also transferred to the new genus. Further, four nominal species, Monolepta estcourtiana Jacoby, 1899, M. contaminata Weise, 1914, M. nodieri Laboissière, 1919, and M. senegalensis Bryant, 1948 are newly synonymised with Afromaculepta decemmaculata (Jacoby, 1886). Three new species of Afromaculepta are described: A. klausi sp. n., A namibiae sp. n., and A. ursulae sp. n. This study, based on revision of material from all major collections, includes distribution maps, an identification key, and a phylogenetic analysis.