A number of changes have occurred since REACH came into force in June 2007. These changes included modifications to the Regulation itself as well as the adoption of 4 Commission Regulations on test methods, fees, the qualifications of the European Chemical Agency's board of appeal, and the rules on the organisation and procedure of that body. In addition, changes to Annexes IV, V and XI of REACH have been adopted by the Commission. The review of Annex I has been completed whilst the review of Annex XIII is still ongoing, although a change to Annex XIII is likely XIII. In addition, REACH is undergoing its first challenge in the European Court if Justice. These changes are unlikely to be the last with further reviews of REACH and the European Chemicals Agency on the horizon in 2012.