The Dulgadir, one of the most successful of the Anatolian Turcoman dynasties, had a long and rocky relationship with the Mamluks, their titular suzerain. Through focus on an iqtā' (military holding) in the northern Syrian heartland that the Mamluks awarded the Dulgadir leadership - the award itself betokening the strength of the Dulgadir and the potential threat that the Mamluks sought to appease - the article goes on to examine the dynamics of the Dulgadir-Mamluk relationship and the part that the Dulgadir played within the Mamluk-Ottoman rivalry, demonstrating that the Dulgadir were wily, worthy, and capable opponents of both the Mamluks and the Ottomans, and that the Mamluks and Ottomans used similar tactics in dealing with the Dulgadir. In returning to an in-depth examination of this DulgadirMamluk iqtā', the article establishes the territorial extent of Dulgadir power and the tribal character of the frontier that separated Dulgadir territory from the Mamluk domain proper, concluding that Mamluk control of the northern Syrian heartland, on the eve of the Ottoman conquest, was already severely weakened as a result of tribal encroachment. The Ottomans, within a few years of the conquest, struck a blow against the Dulgadir in their decision to abolish this iqtā' in northern Syria. Even earlier, however, they had abolished the iqtā's of the Mamluks themselves in what had become the Ottoman Sanjag of Aleppo, but they continue to maintain, until mid-century, at least some of the old Mamluk iqtā' granted to tribesmen, until mid-century, at least some of the old Mamluk iqtā's granted to tribesmen, thus the ultimate demise of the Mamluk iqtā in this area.