This article examines the Anglican missions established at Cape Coast Castle in 1752 and 1766. The first, established by SPG missionary Thomas Thompson, lasted from 1752 to 1755 and his lack of success, coupled with ill health, formed the basis for the second mission, that of Philip Quaque. Quaque, a Fetu youth sent to England for twelve years, returned to Cape Coast in 1766, remaining there until his death in 1816. Of all the insurmountable obstacles created by the slave trade, the most important obstacle Thompson and Quaque faced was the combination of the coastal desire for education and the European, African and Eurafrican opposition to proselytization. For Quaque, his new identity as a Black Protestant, coupled with little direct or indirect support from the SPG, hindered his endeavors. While the missions of Thompson and Quaque have often been viewed as failures they, along with the growing abolitionist attack upon the slave trade, marked a turning point in the relationship between England and the Gold Coast.