A group of twenty-four bookbindings from the last quarter of the fifteenth and first half of the sixteenth century can be identified as very likely executed by bookbinders in Nijmegen. Most of these manuscripts and early printed books contain contemporary ownership inscriptions from people or religious institutions in Nijmegen. Most of the bindings were tooled between ca. 1475 and 1527 with characteristic separate tools whose impressions appear on the bindings in different combinations. The fastenings and the penwork added by hand also support the assignment of these bindings to a single group. Around 1527, the binders switched to the use of rolls, still found in use as late as 1548.