This article explores the phenomenon of globalisation and its effects on the Third World, namely cultural, political and economic dominance by the West. While economic globalisation, accompanied by structural adjustment programs, is purported to enable economic development of the Third World, it has had the opposite effect, namely to tip the economic scales in favour of the West and thereby created further hardships in poorer Third World countries. Globalisation is therefore experienced as a new colonialism undergirded by exploitative political and economic relations. A global ethic is proposed as a way towards countering the ill effects of globalisation. Such an ethic is built on the two-fold foundation of human dignity and human responsibility. An exposition is given of the principles of a global ethic. Within the ambit of such an ethic moral and religious leaders are called upon to attend to the needs of local communities.