This article deals with issues relating to the literary corpus of George of Laodicea. A brief description of the known contents of George’s corpus is provided at the outset in order to correct incomplete or inaccurate lists that appear elsewhere. Two topics are then discussed in more detail. First, reports about George’s lost anti-Manichaean treatise are examined in order to further our understanding of him and his place in the fourth-century Church. It is suggested that he is one of the founders of the Christian anti-Manichean tradition. Second, in response to recent denials of his authorship of the Homoiousian letter written in the summer of 359 on the part of Jeffrey Steenson, Winrich Löhr, and Xavier Morales, it is argued that George played the primary role in its composition.