This essay proposes to energize the mission of the humanities by radically globalizing their subject matter and methods, taking inspiration from the world’s monumental archive of humanistic creativity over 5000 years of recorded experience. It advocates for Comparative Global Humanities as a crucial complement to the more presentist new humanities fields of medical, environmental, or public humanities. Comparative Global Humanities aims to be inclusively global in terms of subject matter and participants, conceptually comparative, and based on rigorous historical and philological research. A Global Humanities for the 21st century is no antiquarian endeavor, but a head-on response to the greatest challenges of our times: systemic racism, inequality, and fundamentalisms, which are rooted in the unresolved aftermath of wars, colonization, and violence, and use classical heritage for nationalist propaganda. To create more equal societies in the present we need to create more equality for other pasts – and learn from all they offer.