Sixth century Antioch is perhaps the best example of state-city resilience in Late Antiquity. Over the century, the city suffered multiple natural disasters, civil strife and external conflict. Scholars have generally accepted that the city declined as a result. This study integrates historical, archaeological and scientific data to illuminate the city’s fate. It concludes that Antioch demonstrated remarkable resilience at the city level throughout the 6th c. The most important factor was the continuous support the city received from the central government.