Head lice are persistent ectoparasites of humans, affecting children as well as adults on all continents. Even though the literature on the subject is extensive, there is still controversy on many crucial elements such as diagnostic procedures and treatment options. In this paper, an overview of different diagnostic methods is given. Furthermore, topical and systemic treatments, mechanical treatments with combs and devices, and alternative treatments such as suffocating agents and essential oils are discussed. One of the elements influencing the treatment of choice is resistance to topical chemical treatments, which has been observed in various European countries. The removal of nits, the eggshells of head lice, is often done for cosmetic purposes. An objective method to measure forces needed to remove nits is described. Finally we discuss the community framework of co-ordinated detection and treatment in which treatments of pediculosis need to be implemented.