This article is a report of an archaeological investigation of the Laloi East Molluscs Site at Kpone, Greater Accra Region, Ghana. Although radiometric dates for this shell midden are currently unavailable, we believe that Laloi East dates to the Later Stone Age. If so, this site would be one of only two LSA sites in Ghana found and excavated along the coast rather than in the forested interior. This article examines shellfish exploitation and other major subsistence strategies of the population that settled the site in the past. The principal cultural materials recovered from the excavations comprised large quantities of molluscs’ remains belonging to a variety of species, other faunal remains, pottery, palm kernel nuts, charcoal, stone slabs, and lithic tools. The combined evidence indicates that molluscs’ exploitation was the principal subsistence strategy of the settlers, undertaken alongside hunting, trapping, herding and the gathering of edible botanical resources such as palm fruits.