This chapter examines the impact on UK higher education of the UK referendum decision to leave the European Union on 23 June 2016. A study of the individual responses of members of governing bodies of the UK institutions and their collective decisions is presented. The likely effects on university funding and research collaboration, on academic staff mobility and research capacity, and on student access are considered. Analysis of the findings indicates that a range of new strategies are being mooted, including the development of new income streams and the expansion of student markets. However, the problem of how best to respond to uncertainty remains.