In discussions about the future of the university, little has been said about how these changes will affect its spatial layout, even though a university’s physical characteristics must complement and strengthen its mission. This chapter addresses that issue and provides an overview of the physical layout of the future university that responds to 21stC drivers of change. It initially describes the development of the mission of the university in the western world and how that mission has determined the basic architectural prototypes of university design since the Middle Ages. Based on this review the authors re-examine these prototypes, identifying the main characteristics of contemporary society that are causing universities to re-evaluate their missions. They then analyse the impact of these changes on the institutional and spatial structure of the university. Four possible scenarios for the design of the future university are explored. The final section summarises the important factors that should be considered by higher education planners seeking to effectively direct the future design of their institutions.