Oppression, exclusion, and alliance are themes common in frontier zones like Suriname where cultures come into contact, collide, and connect. This article shows how Suriname functioned as a frontier not only between European empires but also between cultures and peoples. The meetings, clashes, and exchanges between Jews and Amerindians are a lens through which to analyze this zone of encounter. This relationship also illustrates the dynamics at play on the frontiers of nation and empire. These are places where peoples who are “in between” such as the Portuguese Jews and Amerindians broker between two cultures and two worldviews.