Modern historiography has associated ancient visual representations with the Isiac mysteries. Many scholars have indeed sought to find evidence supporting Apuleius’ or Plutarch’s account in figurative media. This paper reassesses the meaning of these images by focusing more on the context to which they belonged. The Isiac mysteries definitely left their trace in the figurative tradition of antiquity in the form of a visual indicator, the mystical cista. This paper builds a sort of “cultural biography” of this motif by exploring its readings and usages from one medium to another, one context to another.