Copying Mashaf Al-Quran with handwriting became a tradition of the Malay community once upon a time as a vehicle for the spread of Islam in the archipelago. As a result, the scientific heritage of the Islamic community in the form of manuscripts or printed materials produced with high quality. Therefore, this article’s purpose is to elucidate the history of the al-Quran manuscript writing in Indonesia, and also explain in detail about the history of al-Quran manuscript writing in Madura besides the focuses on the codicology found in al-Quran manuscript MSS 4322 which has been collected in the National Library of Malaysia. This study uses a qualitative approach with philological methods. The findings show that the history of the writing of the Qurʾan in Madura took place in line with the arrival and spread of Islam in the region of Madura in the 15th century AD. Based on the codicological analysis it was found that this manuscript came from the country of Madura, Indonesia. This is because it was written in the manuscripts that Pangeran Jimat was ruler of Madura in the 18th century AD. The writing uses daluang paper with a naskhi style writing model. This research shows that the rasm used in the mashaf tends more to rasm Imlaʾi. The beautiful illumination is with the drawing of spiral leaves as a result of a combination of various colors. The findings show that the author submits a proposal so that this manuscript can be digitized as a scholarly heritage so that it will last for a long time and help the community to more easily access it in a digital form that is sustainable in nature. In conclusion, this manuscript of the Qurʾan is a masterpiece that will enhance the dignity and writings of previous scholars academically and more authoritatively to the digital generation, especially in the field of the Qurʾan.