H. T. Hassan, M. A. Khokher and N. Ahmed

Haematologia , Vol. 30, No. 3, pp. 167 – 176 (2000) Ó VSP 2000. Paper Synthetic cytokines containing interleukin-3 exert potent megakaryopoietic activity N. AHMED, M. A. KHOKHER and H. T. HASSAN ∗ Division of Biomedical Sciences, School of Health Sciences, University of Wolverhampton, United

Susanne Braun, Helmut H. Gerhartz and Helga M. Schmetzer

Haematologia , Vol. 30, No. 4, pp. 271 – 288 (2000) Ó VSP 2000. Paper Lymphokine-activated killer (LAK) cells and cytokines synergize to kill clonal cells in acute myeloid leukemia (AML) in vitro SUSANNE BRAUN 1 , HELMUT H. GERHARTZ 2 and HELGA M. SCHMETZER 3 , ∗ 1 Charité, Campus Virchow

Marion J.M. Bergamin-Sassen, Robert M. Hoek, Wessel Lageweg, August B. Smit and Marijke DE JONG-BRINK

SCHISTOSOMA PARASITES EVOKE STRESS RESPONSES IN THEIR SNAIL HOST BY A CYTOKINE-LIKE FACTOR INTERFERING WITH NEURO-ENDOCRINE MECHANISMS by MARIJKE DE JONG-BRINK*, ROBERT M. HOEK, AUGUST B. SMIT, MARION J.M. BERGAMIN-SASSEN and WESSEI, LAGEWEG (Graduate School of Neurosciences Amsterdam, Research

Alexandru F. Deftu, Paolo Fiorenzani, Ilaria Ceccarelli, Jessica Pinassi, Martina Gambaretto, Violeta Ristoiu, Luana R. Paulesu and Anna-Maria Aloisi

Introduction Cytokines are small proteins released by immune and non-immune cells that are involved in different signaling pathways throughout the entire central nervous system (CNS). Immune cells and resident microglia which act as CNS sentinels and help in maintaining its correct function

Anat Elmann, Alona Telerman, Rivka Ofir and Yoel Kashman

Atopic dermatitis is a chronic and recurring inflammatory disease of the skin. This study aimed to evaluate the anti-inflammatory properties of pulichalconoid B, a chalcone that we have isolated from the plant Pulicaria incisa. The in vivo activity of pulichalconoid B was evaluated using the oxazolone model of cutaneous dermatitis and its in vitro activity was studied using isolated splenocytes. Changes in ear thickness, myeloperoxidase activity and production of different cytokines were considered to be indicators of dermal inflammation. Mice that were treated with pulichalconoid B showed a significantly decreased response to delayed-type hypersensitivity induced by oxazolone. Pulichalconoid B significantly reduced oxazolone-induced ear edema, inhibited myeloperoxidase activity and downregulated several cytokines. Pulichalconoid B also inhibited the secretion of cytokines from activated splenocytes. The data suggest that pulichalconoid B may be useful in treating skin inflammations.

bridging the unjustified gap be- tween the ‘old’ classical and the ‘new’ molecular clinical genetics. KÁROLY MÉHES Cytokines in the Treatment of Hematopoietic Failure A. Ganser and D. Hoelzer (Eds) Marcell Dekker, New York (1999) ISBN: 0-8247-0193-3; Price: $165.00 In the past decade the use of many

İlhan Yaylim, Emel Demiralp, Hülya Yilmaz, Oguz Öztürk, Makbule Aydin, Bedia Agaçhan and Turgay İsbir

¯ -thalassaemia, among which the impairment of neurophil and macrophage phagocytic and killing functions and the production of some cytokines are the most important. It is known that interleukin-6 (IL-6) and interleukin-8(IL-8) are important components of the pro-in ammatory response. The plasma levels of these

M. Hino, T. Kumura, N. Tatsumi, T. Yamane, H. Ohkura, T. Takubo, T. Kamitani and K. Ohta

City University Medical School, 1-4-3, Asahimachi, Abeno-ku, Osaka 545-8585, Japan Key words : IL-18; hematological disorders. Interleukin-18 (IL-18), originary called interferon (IFN γ )-inducing factor, is a recently cloned cytokine of approximately 18 kDa. Its major activity is the induction of IFN

Nakao, Tatsumi, Koh, Kumura, Aoyama, Kamitani, Kinoshita, Hino, Nakamae, Takubo and Yamane

interferon (IFN ° )-inducing factor, is a multifunctional cytokine of approximately 18 kDa synthesized by Kupffer cells and activated macrophages [2]. In 1996, human IL-18 cDNA was cloned and expressed in Escherichia coli , and it has been found that human IL-18 has the capacity to stimulate cytotoxic

Nakao, Nakamae, Ohta, Takubo, Aoyama, Ohta, Yamamura, Kumura, Kamitani, Koh, Yamane, Kanashima, Tatsumi and Hino

multifunctional cytokine consisting of a single 18.3 kD peptide synthesized by Kuppfer cells and activated macrophages [1]. Human IL-18 cDNA has been cloned and expressed Escherichia coli [1]. An enzyme-linked immunosorbent assay (ELISA) system for human IL-18 using two mouse monoclonal antibodies has been