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3D printing technology is a powerful learning tool that can involve students in active learning, design thinking, and problem-solving. It creates opportunities for integrating science, engineering, technology, and mathematics with other disciplines. In this chapter, we describe the benefits of 3D printing technology for teaching science and discuss a theoretical framework for designing 3D printing problem- and project-based learning in science followed by practical recommendations for creating 3D printing instructional units that can be integrated into a formal curriculum. In conclusion, we provide an example of a 3D printing project that was implemented with preservice elementary teachers in a science methods course.