A comprehensive review of post-market clinical studies performed in adults with an Asian probiotic formulation
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Abstract
Probiotics as dietary supplements have been readily accepted by Asian populations. Use of certain probiotic preparations is widespread and the number of clinical trials undertaken with such products is unparalleled in western scientific literature. One such preparation, containing a combination of Enterococcus faecium R0026 and Bacillus subtilis R0179, has 23 publications on post-market clinical studies involving over 1,800 adults. The majority of these publications are printed in Chinese and Korean journals. This review examines the clinical findings with this probiotic combination. As mono-therapy, it has been used to overcome symptoms associated with chronic diarrhoea and irritable bowel syndrome. It has been used as co-adjuvant therapy with sulfasalazine and mesalazine to improve remission times in mild to moderate Ulcerative Colitis and to improve compliance with conventional triple therapy for Helicobacter pylori eradication. While the much of the data is preliminary and the study designs require refinement, the contribution of these trials should not be ignored. The information derived in this review will provide practitioners with practical information on appropriate applications for probiotic supplements, expected outcomes, dosing regimes, safety and reported adverse events. Furthermore, identification of problems in these trials should help researchers design better clinical trials when investigating probiotic products.
-
Chinese Medical Association (CMA), 2001. The recommendations for the standardization of the diagnosis and treatment of inflammatory bowel disease. Chinese Digestive Journal 21: 236-239.
'The recommendations for the standardization of the diagnosis and treatment of inflammatory bowel disease ' , , .
-
Chang, F.Y., Lu, C.L., Chen, C.Y. and Luo, J.C., 2007. Efficacy of dioctahedral smectite in treating patients of diarrhea-predominant irritable bowel syndrome. Journal of Gastroenterology and Hepatology 22: 2266-2272.
'Efficacy of dioctahedral smectite in treating patients of diarrhea-predominant irritable bowel syndrome ' () 22 Journal of Gastroenterology and Hepatology : 2266 -2272.
-
Chen, C.N. and Zhu, J., 2007. Three kinds of probiotics in the treatment of acute diarrhea drug economic evaluation. Strait Pharmaceutical Journal 19: 83-84.
'Three kinds of probiotics in the treatment of acute diarrhea drug economic evaluation ' () 19 Strait Pharmaceutical Journal : 83 -84.
-
Chen, Y., 2007. Clinical effect of the combined treatment with sulfasalazine and Medilac-S for Ulcerative Colitis. Journal of Military Surgeon in Southwest China 9: 32-33.
'Clinical effect of the combined treatment with sulfasalazine and Medilac-S for Ulcerative Colitis ' () 9 Journal of Military Surgeon in Southwest China : 32 -33.
-
Cheng, S.L., Dong, X., Lin, Q. and Liu, T., 2008. Severe post-traumatic adult acute respiratory distress syndrome treatment. Practical Journal of Medicine and Pharmacy 25: 30-31.
'Severe post-traumatic adult acute respiratory distress syndrome treatment ' () 25 Practical Journal of Medicine and Pharmacy : 30 -31.
-
European Food Safety Authority (EFSA), 2007. Introduction of a Qualified Presumption of Safety (QPS) approach for assessment of selected microorganisms referred to EFSA - Opinion of the Scientific Committee. The EFSA Journal 587: 1-16.
'Introduction of a Qualified Presumption of Safety (QPS) approach for assessment of selected microorganisms referred to EFSA -Opinion of the Scientific Committee ' , , .
-
Feng, H., Ni, J. and Li, Y., 2007. Efficacy of Tegaserod combined with Medilac-S on constipation-dominant irritable bowel syndrome. Chinese Journal of Gastroenterology and Hepatology 16: 424-426, 429.
-
Foulquié Moreno, M.R., Sarantinopoulos, P., Tsakalidou, E. and De Vuyst, L., 2006. The role and application of enterocci in food and health. International Journal of Food Microbiology 106: 270-285.
'The role and application of enterocci in food and health ' () 106 International Journal of Food Microbiology : 270 -285.
-
Franz, C., Stiles, M., Schleifer, K. and Holzapfel, W., 2003. Enterococci in foods - a conundrum for food safety. International Journal of Food Microbiology 88: 105-122.
'Enterococci in foods - a conundrum for food safety ' () 88 International Journal of Food Microbiology : 105 -122.
-
Gong, M. and Xu, L., 2007. Medilac-S, Pei Fei Kang combined with Etiasa® in the treatment of 56 cases of Ulcerative Colitis. Shandong Chinese Medicine 47: 113-114.
'Medilac-S, Pei Fei Kang combined with Etiasa® in the treatment of 56 cases of Ulcerative Colitis ' () 47 Shandong Chinese Medicine : 113 -114.
-
Guo, M., Li, Y.Q. and Zuo, X.L., 2006. The role of Treg/CD4 + T in the pathogenesis and prevention of bowel dysfunction after acute enteritis in rats. Chinese Journal of Digestion 26: 435-439.
'The role of Treg/CD4 + T in the pathogenesis and prevention of bowel dysfunction after acute enteritis in rats ' () 26 Chinese Journal of Digestion : 435 -439.
-
Guo, M., Wang, J., Wang, F.-C., Li, N., Weng, Y., Jia, Z.-W. and Li, Y.Q., 2007. Effects of various treatments on bowel function after Shigella flexerni infection in rats. Journal of Shandong University (Health Sciences) 45: 416-419.
'Effects of various treatments on bowel function after Shigella flexerni infection in rats ' () 45 Journal of Shandong University (Health Sciences) : 416 -419.
-
Guo, S., Han, Y., Zhang, X., Lu, B., Yi, C., Zhang, H., Ma, X., Wang, D., Yang, L., Fan, X., Liu, Y., Lu, K. and Li, H., 2008. Human facial allotransplantation: a 2-year follow-up study. The Lancet 372: 631-638.
'Human facial allotransplantation: a 2-year follow-up study ' () 372 The Lancet : 631 -638.
-
Guo, S. and Sun, J., 2007. Medilac-S and coloclysis combined treatment of 66 cases of Ulcerative Colitis. Chinese Journal of Misdiagnosis. 7: 5360-5361.
'Medilac-S and coloclysis combined treatment of 66 cases of Ulcerative Colitis ' () 7 Chinese Journal of Misdiagnosis. : 5360 -5361.
-
He, G.Z. and He, Y.H., 2008. Clinical analysis of 112 cases of chronic diarrhea treated by Medilac-S. Hainan Medical Journal 19: 14, 46.
-
Kayser, F., 2003. Safety aspects of enterococci from the medical point of view. International Journal of Food Microbiology 88: 255-262.
'Safety aspects of enterococci from the medical point of view ' () 88 International Journal of Food Microbiology : 255 -262.
-
Kim, Y.G., Moon, J.T., Lee, K.M., Chon, N.R. and Park, H., 2006. The effects of probiotics on symptoms of irritable bowel syndrome. Korean Journal of Gastroenterology 47: 413-419.
'The effects of probiotics on symptoms of irritable bowel syndrome ' () 47 Korean Journal of Gastroenterology : 413 -419.
-
Lee, K., Lee, M. and Lee, Y.H., 2008. Safety assessment of commercial Enterococcus probiotics in Korea. Journal of Microbiology and Biotechnology 18: 942-945.
'Safety assessment of commercial Enterococcus probiotics in Korea ' () 18 Journal of Microbiology and Biotechnology : 942 -945.
-
Li, H., Zhang, H. and Daniel, D., 2007. Probiotics retention enema treatment of antibiotic-associated diarrhea clinical observation. Journal of Practical Medicine 23: 1380-1382.
'Probiotics retention enema treatment of antibiotic-associated diarrhea clinical observation ' () 23 Journal of Practical Medicine : 1380 -1382.
-
Li, S.C., Cao, C. and Tang, W.H., 2006. Clinical observation of Medilac-S-and triazine (mesalazine) combined treatment of Ulcerative Colitis. Modern Journal of Integrated Traditional Chinese and Western Medicine 15: 900-901.
'Clinical observation of Medilac-S-and triazine (mesalazine) combined treatment of Ulcerative Colitis ' () 15 Modern Journal of Integrated Traditional Chinese and Western Medicine : 900 -901.
-
Liao, Z., Chen, J. and Zhang, C.H., 2007. Post-liver transplantation pseudomembranous colitis two cases. Clinical Journal of the Medical Officer 36: 236.
-
Lin, Z., 2007. Clinical observation of Medilac-S in the treatment of chronic diarrhea. Medical Innovation Research 4: 100.
-
Lu, D. and Dong, Y.K., 2007. Efficacy of combination of Smectite with Medilac-S for diarrheal-type irritable bowel syndrome. Chinese Journal of New Drugs 16: 319-321.
'Efficacy of combination of Smectite with Medilac-S for diarrheal-type irritable bowel syndrome ' () 16 Chinese Journal of New Drugs : 319 -321.
-
Ogier, J. and Serror, P., 2008. Safety assessment of dairy microorganisms: the Enterococcus genus. International Journal of Food Microbiology 126: 291-301.
'Safety assessment of dairy microorganisms: the Enterococcus genus ' () 126 International Journal of Food Microbiology : 291 -301.
-
Park, S.K., Park, D.I., Choi, J.S., Kang, M.S., Park, J.H., Kim, H.J., Cho, Y.K., Sohn, C.I., Jeon, W.K. and Kim, B.I., 2007. The effect of probiotics on Helicobacter pylori eradication. Hepato-Gastroenterology 54: 2032-2036.
'The effect of probiotics on Helicobacter pylori eradication ' () 54 Hepato-Gastroenterology : 2032 -2036.
-
Su, H., Sheng, J., Chen, Z., Li, A., Yan, W., Yu, D., Zhang, Y. and Li, S., 2006. Clinical efficacy of glutamine compound enteric capsules in the treatment of diarrhea-predominant irritable bowel syndrome. Chinese Journal of Gastroenterology 11: 602-604.
'Clinical efficacy of glutamine compound enteric capsules in the treatment of diarrhea-predominant irritable bowel syndrome ' () 11 Chinese Journal of Gastroenterology : 602 -604.
-
Sutherland, L.R., May, G.R. and Shaffer, E.A., 1993. Sulfasalazine revisited: a meta-analysis of 5-aminosalicylic acid in the treatment of Ulcerative Colitis. Annals of Internal Medicine 118: 540-549.
'Sulfasalazine revisited: a meta-analysis of 5-aminosalicylic acid in the treatment of Ulcerative Colitis ' () 118 Annals of Internal Medicine : 540 -549.
-
Tang, S.Y., Zhong, X.-B., Chen, L.-Y. and Lan, Y.-J., 2007. Antibiotic susceptibility in vitro of microecologics commonly used in hospitals. Chinese Journal of Microecology 19: 27.
-
Tompkins, T.A., Hagen, K.E., Wallace, T.D. and Fillion-Forte, V., 2008. Safety evaluation of two bacterial strains used in Asian probiotic products. Canadian Journal of Microbiology 54: 391-400.
'Safety evaluation of two bacterial strains used in Asian probiotic products ' () 54 Canadian Journal of Microbiology : 391 -400.
-
Van Niel, C.W., Feudtner, C., Garrison, M.M. and Christakis, D.A., 2002. Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis. Pediatrics 109: 678-684.
Lactobacillus , ().
-
Verdu, E.F., Bercik, P., Huang, X.X., Lu, J., Al-Mutawaly, N., Sakai, H., Tompkins, T.A., Croitoru, K., Tsuchida, E., Perdue, M. and Collins, S.M., 2008. The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection. American Journal of Physiology. Gastrointestinal and Liver Physiology 295: G664-670.
'The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection ' () 295 American Journal of Physiology. Gastrointestinal and Liver Physiology : G664 -670.
-
Wang, C.R. and Jin, J., 2006. Effect of Medilac-S on diarrhea caused by an imbalance of intestinal flora. Journal of Medical Forum. 27: 74-75.
'Effect of Medilac-S on diarrhea caused by an imbalance of intestinal flora ' () 27 Journal of Medical Forum. : 74 -75.
-
Wang, C.R. and Liu, Z., 2007. Medilac-S and sulfasalazine treatment of Ulcerative Colitis. Journal of Medical Forum 28: 77-78.
'Medilac-S and sulfasalazine treatment of Ulcerative Colitis ' () 28 Journal of Medical Forum : 77 -78.
-
Wang, H.J., Liang, X.M., Yu, Z.L., Liu, X.G., Yu, Y.Y. and Cheng, L.F., 2004. Efficacy and safety of Bacillus subtilis and Enterococcus faecium in treatment of acute and chronic diarrhea. Chinese Journal of New Drugs 13: 452-455.
'Efficacy and safety of Bacillus subtilis and Enterococcus faecium in treatment of acute and chronic diarrhea ' () 13 Chinese Journal of New Drugs : 452 -455.
-
Wang, Y.Z., 2008. Clinical observation of the combination of Medilac-S and Smecta in the treatment of chronic diarrhea. Chinese Journal of Trauma and Disability Medicine 16: 70-71.
'Clinical observation of the combination of Medilac-S and Smecta in the treatment of chronic diarrhea ' () 16 Chinese Journal of Trauma and Disability Medicine : 70 -71.
-
Wu, Q.-R., Zhou, J., He, J.-D., Wang, Y.P., Yang, X.-R. and Zhang, L., 2008. Probiotic agents for Ulcerative Colitis: a systematic review. Chinese Journal of Evidence-Based Medicine 8: 315-321.
'Probiotic agents for Ulcerative Colitis: a systematic review ' () 8 Chinese Journal of Evidence-Based Medicine : 315 -321.
-
Xiang, J.Y. and Feng, Y.C., 2006. Therapeutic effect of Medilac-S combined with sulfasalazine in treatment of Ulcerative Colitis: an analysis of 22 cases. World Chinese Digestive Journal 14: 1742-1744.
'Therapeutic effect of Medilac-S combined with sulfasalazine in treatment of Ulcerative Colitis: an analysis of 22 cases ' () 14 World Chinese Digestive Journal : 1742 -1744.
-
Yang, G., Wang, Q., Gao, Y.-J., Zhang, W.P., Wang, X. and Qiang, T., 2008. The effect of a SASP and Medilac-S combination enema on the remission of Ulcerative Colitis. Chinese Journal of Misdiagnosis 8: 4056-4057.
'The effect of a SASP and Medilac-S combination enema on the remission of Ulcerative Colitis ' () 8 Chinese Journal of Misdiagnosis : 4056 -4057.
-
Yu, H.-B., Dai, L., Peng, H.Y. and Zuo, Z., 2006. Experimental studies on the effects mechanism of treatment rat nonalcoholic steatohepatitis model by microbial pharmaceutics. Chinese Journal of Clinical Gastroenterology 18: 350-352.
'Experimental studies on the effects mechanism of treatment rat nonalcoholic steatohepatitis model by microbial pharmaceutics ' () 18 Chinese Journal of Clinical Gastroenterology : 350 -352.
-
Yuan, Q., Sun, T.Y. and Wang, H.J., 2004. Effects of Bacillus subtilis and Enterococcus faecium on bacterial translocation in cirrhotic rats. Chinese Journal of New Drugs 13: 988-990.
'Effects of Bacillus subtilis and Enterococcus faecium on bacterial translocation in cirrhotic rats ' () 13 Chinese Journal of New Drugs : 988 -990.
-
Yuan, S., Mahe, M. and Li, 2008. Analysis of the effect of Medilac-S and sulfasalazine co-treatment of Ulcerative Colitis. Chinese Journal of Modern Applied Pharmacy 25: 749-750.
'Analysis of the effect of Medilac-S and sulfasalazine co-treatment of Ulcerative Colitis ' () 25 Chinese Journal of Modern Applied Pharmacy : 749 -750.
-
Zeng, Q., 2008. Clinical observation of Medilac.-S combined with sulfasalazine in the treatment of Ulcerative Colitis. Journal of Practical Medical Technology 15: 1271-1272.
-
Zhang, L., 2006. Using of Medilac-S and herbal coloclysis in the treatment of Ulcerative Colitis. Liaoning Chinese Medical Journal 33: 990.
-
Zhao, H.Y., Wang, H.J., Lu, Z. and Xu, S.Z., 2004. Intestinal microflora in patients with liver cirrhosis. Chinese Journal of Digestive Diseases 5: 64-67.
'Intestinal microflora in patients with liver cirrhosis ' () 5 Chinese Journal of Digestive Diseases : 64 -67.
-
Zhao, H.Y., Wang, H.J., Lu, Z. and Xu, S.Z., 2005. Effects of probiotics for intestinal flora and T lymphocyte subsets in patients with liver cirrhosis. Chinese Journal of New Drugs 14: 1347-1349.
'Effects of probiotics for intestinal flora and T lymphocyte subsets in patients with liver cirrhosis ' () 14 Chinese Journal of New Drugs : 1347 -1349.
-
Zhong, Y.T., Zhang, W.P., Wang, X.H., Huang, Z. and Ma, L.L., 2006. The bacteriostatic effect of Medilac-Vita on enteric pathogen and conditioned pathogen and their bacterial L form. Journal of Gannan Medical University 26: 487-488.
'The bacteriostatic effect of Medilac-Vita on enteric pathogen and conditioned pathogen and their bacterial L form ' () 26 Journal of Gannan Medical University : 487 -488.
-
Ziemniak, W., 2006. Efficacy of Helicobacter pylori eradication taking into account its resistance to antibiotics. Journal of Physiology and Pharmacology 57: 123-141.
'Efficacy of Helicobacter pylori eradication taking into account its resistance to antibiotics ' () 57 Journal of Physiology and Pharmacology : 123 -141.
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A comprehensive review of post-market clinical studies performed in adults with an Asian probiotic formulation
In: Beneficial Microbesttompkins@lallemand.com
Search for other papers by T.A. Tompkins in
Current site
Google Scholar
PubMed
Search for other papers by X. Xu in
Current site
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PubMed
Search for other papers by J. Ahmarani in
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PubMed
Abstract
Probiotics as dietary supplements have been readily accepted by Asian populations. Use of certain probiotic preparations is widespread and the number of clinical trials undertaken with such products is unparalleled in western scientific literature. One such preparation, containing a combination of Enterococcus faecium R0026 and Bacillus subtilis R0179, has 23 publications on post-market clinical studies involving over 1,800 adults. The majority of these publications are printed in Chinese and Korean journals. This review examines the clinical findings with this probiotic combination. As mono-therapy, it has been used to overcome symptoms associated with chronic diarrhoea and irritable bowel syndrome. It has been used as co-adjuvant therapy with sulfasalazine and mesalazine to improve remission times in mild to moderate Ulcerative Colitis and to improve compliance with conventional triple therapy for Helicobacter pylori eradication. While the much of the data is preliminary and the study designs require refinement, the contribution of these trials should not be ignored. The information derived in this review will provide practitioners with practical information on appropriate applications for probiotic supplements, expected outcomes, dosing regimes, safety and reported adverse events. Furthermore, identification of problems in these trials should help researchers design better clinical trials when investigating probiotic products.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 0 | 0 | 0 |
| Full Text Views | 176 | 171 | 45 |
| PDF Views & Downloads | 123 | 117 | 9 |
