Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster
In: Beneficial MicrobesDepartment of Public Health, Xi’an Jiaotong-Liverpool University, Suzhou 215123, China P.R.
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Individuals in a community who developed irritable bowel syndrome (IBS) after major floods have significant mental health impairment. We aimed to determine if Bifidobacterium infantis M-63 was effective in improving symptoms, psychology and quality of life measures in flood-affected individuals with IBS and if the improvement was mediated by gut microbiota changes. Design was non-randomised, open-label, controlled before-and-after. Of 53 participants, 20 with IBS were given B. infantis M-63 (1×109 cfu/sachet/day) for three months and 33 were controls. IBS symptom severity scale, hospital anxiety and depression scale, SF-36 Questionnaire, hydrogen breath testing for small intestinal bacterial overgrowth and stools for 16S rRNA metagenomic analysis were performed before and after intervention. 11 of 20 who were given probiotics (M-63) and 20 of 33 controls completed study as per-protocol. Mental well-being was improved with M-63 vs controls for full analysis (P=0.03) and per-protocol (P=0.01) populations. Within-group differences were observed for anxiety and bodily pain (both P=0.04) in the M-63 per-protocol population. Lower ratio of Firmicutes/Bacteroidetes was observed with M-63 vs controls (P=0.01) and the lower ratio was correlated with higher post-intervention mental score (P=0.04). B. infantis M-63 is probably effective in improving mental health of victims who developed IBS after floods and this is maybe due to restoration of microbial balance and the gut-brain axis. However, our conclusion must be interpreted within the context of limited sample size. The study was retrospectively registered on 12 October 2017 and the Trial Registration Number (TRN) was NCT03318614.
-
Allen, A.P., Clarke, G., Cryan, J.F., Quigley, E.M.M. and Dinan, T.G., 2017. Bifidobacterium infantis 35624 and other probiotics in the management of irritable bowel syndrome. Strain specificity, symptoms and mechanisms. Current Medical Research and Opinion 33: 1349-1351.
'Bifidobacterium infantis 35624 and other probiotics in the management of irritable bowel syndrome ' () 33 Current Medical Research and Opinion : 1349 -1351.
-
Armijo-Olivo, S., Warren, S. and Magee, D., 2009. Intention to treat analysis, compliance, drop-outs and how to deal with missing data in clinical research: a review. Physical Therapy Reviews 14: 36-49.
'Intention to treat analysis, compliance, drop-outs and how to deal with missing data in clinical research: a review ' () 14 Physical Therapy Reviews : 36 -49.
-
Bauserman, M. and Michail, S., 2005. The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial. Journal of Pediatrics 147: 197-201.
'The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial ' () 147 Journal of Pediatrics : 197 -201.
-
Carmody, R.N., Gerber, G.K., Luevano Jr., J.M., Gatti, D.M., Somes, L., Svenson, K.L. and Turnbaugh, P.J., 2015. Diet dominates host genotype in shaping the murine gut microbiota. Cell Host and Microbe 17: 72-84.
'Diet dominates host genotype in shaping the murine gut microbiota ' () 17 Cell Host and Microbe : 72 -84.
-
Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J. and Dinan, T.G., 2008. The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat. Journal of Psychiatric Research 43: 164-174.
'The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat ' () 43 Journal of Psychiatric Research : 164 -174.
-
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J.F. and Dinan, T.G., 2010. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 170: 1179-1188.
'Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression ' () 170 Neuroscience : 1179 -1188.
-
Dinan, T.G., Stanton, C. and Cryan, J.F., 2013. Psychobiotics: a novel class of psychotropic. Biological Psychiatry 74: 720-726.
'Psychobiotics: a novel class of psychotropic ' () 74 Biological Psychiatry : 720 -726.
-
Erdogan, A., Rao, S.S., Gulley, D., Jacobs, C., Lee, Y.Y. and Badger, C., 2015. Small intestinal bacterial overgrowth: duodenal aspiration vs glucose breath test. Neurogastroenterology and Motility 27: 481-489.
'Small intestinal bacterial overgrowth: duodenal aspiration vs glucose breath test ' () 27 Neurogastroenterology and Motility : 481 -489.
-
Fernandez, A., Black, J., Jones, M., Wilson, L., Salvador-Carulla, L., Astell-Burt, T. and Black, D., 2015. Flooding and mental health: a systematic mapping review. PLoS ONE 10: e0119929.
'Flooding and mental health: a systematic mapping review ' () 10 PLoS ONE : e0119929.
-
Francis, C.Y., Morris, J. and Whorwell, P.J., 1997. The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Alimentary Pharmacology and Therapeutics 11: 395-402.
'The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress ' () 11 Alimentary Pharmacology and Therapeutics : 395 -402.
-
Gawronska, A., Dziechciarz, P., Horvath, A. and Szajewska, H., 2007. A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children. Alimentary Pharmacology and Therapeutics 25: 177-184.
'A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children ' () 25 Alimentary Pharmacology and Therapeutics : 177 -184.
-
Giannetti, E., Maglione, M., Alessandrella, A., Strisciuglio, C., De Giovanni, D., Campanozzi, A., Miele, E. and Staiano, A., 2017. A mixture of 3 bifidobacteria decreases abdominal pain and improves the quality of life in children with irritable bowel syndrome: a multicenter, randomized, double-blind, placebo-controlled, crossover trial. Journal of Clinical Gastroenterology 51: e5-e10.
'A mixture of 3 bifidobacteria decreases abdominal pain and improves the quality of life in children with irritable bowel syndrome: a multicenter, randomized, double-blind, placebo-controlled, crossover trial ' () 51 Journal of Clinical Gastroenterology : e5 -e10.
-
Guyonnet, D., Chassany, O., Ducrotte, P., Picard, C., Mouret, M., Mercier, C.H. and Matuchansky, C., 2007. Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial. Alimentary Pharmacology and Therapeutics 26: 475-486.
'Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial ' () 26 Alimentary Pharmacology and Therapeutics : 475 -486.
-
Ishizeki, S., Sugita, M., Takata, M. and Yaeshima, T., 2013. Effect of administration of bifidobacteria on intestinal microbiota in low-birth-weight infants and transition of administered bifidobacteria: a comparison between one-species and three-species administration. Anaerobe 23: 38-44.
'Effect of administration of bifidobacteria on intestinal microbiota in low-birth-weight infants and transition of administered bifidobacteria: a comparison between one-species and three-species administration ' () 23 Anaerobe : 38 -44.
-
Jafari, N., Shahsanai, A., Memarzadeh, M. and Loghmani, A., 2011. Prevention of communicable diseases after disaster: a review. Journal of Research in Medical Sciences 16: 956-962.
'Prevention of communicable diseases after disaster: a review ' () 16 Journal of Research in Medical Sciences : 956 -962.
-
Kajander, K., Hatakka, K., Poussa, T., Farkkila, M. and Korpela, R., 2005. A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. Alimentary Pharmacology and Therapeutics 22: 387-394.
'A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention ' () 22 Alimentary Pharmacology and Therapeutics : 387 -394.
-
Kechagia, M., Basoulis, D., Konstantopoulou, S., Dimitriadi, D., Gyftopoulou, K., Skarmoutsou, N. and Fakiri, E.M., 2013. Health benefits of probiotics: a review. ISRN Nutrition 2013: 7.
'Health benefits of probiotics: a review ' () 2013 ISRN Nutrition : 7.
-
Khalighi, A.R., Khalighi, M.R., Behdani, R., Jamali, J., Khosravi, A., Kouhestani, S., Radmanesh, H., Esmaeelzadeh, S. and Khalighi, N., 2014. Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) – a pilot study. Indian Journal of Medical Research 140: 604-608.
'Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) – a pilot study ' () 140 Indian Journal of Medical Research : 604 -608.
-
Kim, H.J., Camilleri, M., McKinzie, S., Lempke, M.B., Burton, D.D., Thomforde, G.M. and Zinsmeister, A.R., 2003. A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome. Alimentary Pharmacology and Therapeutics 17: 895-904.
'A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome ' () 17 Alimentary Pharmacology and Therapeutics : 895 -904.
-
Kim, H.J., Vazquez Roque, M.I., Camilleri, M., Stephens, D., Burton, D.D., Baxter, K., Thomforde, G. and Zinsmeister, A.R., 2005. A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterology and Motility 17: 687-696.
'A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating ' () 17 Neurogastroenterology and Motility : 687 -696.
-
LoCascio, R.G., Desai, P., Sela, D.A., Weimer, B. and Mills, D.A., 2010. Broad conservation of milk utilization genes in Bifidobacterium longum subsp. infantis as revealed by comparative genomic hybridization. Applied and Environmental Microbiology 76: 7373-7381.
'Broad conservation of milk utilization genes in Bifidobacterium longum subsp ' () 76 Applied and Environmental Microbiology : 7373 -7381.
-
Lyte, M., Varcoe, J.J. and Bailey, M.T., 1998. Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation. Physiology and Behavior 65: 63-68.
'Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation ' () 65 Physiology and Behavior : 63 -68.
-
Marshall, J.K., Thabane, M., Garg, A.X., Clark, W.F., Salvadori, M. and Collins, S.M., 2006. Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery. Gastroenterology 131: 445-450.
'Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery ' () 131 Gastroenterology : 445 -450.
-
McKernan, D.P., Fitzgerald, P., Dinan, T.G. and Cryan, J.F., 2010. The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat. Neurogastroenterology and Motility 22: 1029-1035.
'The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat ' () 22 Neurogastroenterology and Motility : 1029 -1035.
-
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.F., Rougeot, C., Pichelin, M., Cazaubiel, M. and Cazaubiel, J.M., 2011a. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition 105: 755-764.
'Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects ' () 105 British Journal of Nutrition : 755 -764.
-
Messaoudi, M., Violle, N., Bisson, J.F., Desor, D., Javelot, H. and Rougeot, C., 2011b. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes 2: 256-261.
'Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers ' () 2 Gut Microbes : 256 -261.
-
Neufeld, K.M., Kang, N., Bienenstock, J. and Foster, J.A., 2011. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterology and Motility 23: 255-264.
'Reduced anxiety-like behavior and central neurochemical change in germ-free mice ' () 23 Neurogastroenterology and Motility : 255 -264.
-
Nobaek, S., Johansson, M.L., Molin, G., Ahrne, S. and Jeppsson, B., 2000. Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. American Journal of Gastroenterology 95: 1231-1238.
'Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome ' () 95 American Journal of Gastroenterology : 1231 -1238.
-
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G.C., Kiely, B., Collins, J.K., Shanahan, F. and Quigley, E.M., 2005. Lactobacillus and Bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 128: 541-551.
'Lactobacillus and Bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles ' () 128 Gastroenterology : 541 -551.
-
Odamaki, T., Kato, K., Sugahara, H., Hashikura, N., Takahashi, S., Xiao, J.-Z., Abe, F. and Osawa, R., 2016. Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study. BMC Microbiology 16: 90.
'Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study ' () 16 BMC Microbiology : 90.
-
Picard, C., Fioramonti, J., Francois, A., Robinson, T., Neant, F. and Matuchansky, C., 2005. Bifidobacteria as probiotic agents – physiological effects and clinical benefits. Alimentary Pharmacology & Therapeutics 22: 495-512.
'Bifidobacteria as probiotic agents – physiological effects and clinical benefits ' () 22 Alimentary Pharmacology & Therapeutics : 495 -512.
-
Rajilić-Stojanović, M., Biagi, E., Heilig, H.G.H.J., Kajander, K., Kekkonen, R.A., Tims, S. and De Vos, W.M., 2011. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology 141: 1792-1801.
'Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome ' () 141 Gastroenterology : 1792 -1801.
-
Sararaks, S., Azman, A.B., Low, L.L., Rugayah, B., Aziah, A.M., Hooi, L.N., Abdul Razak, M., Norhaya, M.R., Lim, K.B., Azian, A.A. and Geeta, S., 2005. Validity and reliability of the SF-36: the Malaysian context. Medical Journal of Malaysia 60: 163-179.
'Validity and reliability of the SF-36: the Malaysian context ' () 60 Medical Journal of Malaysia : 163 -179.
-
Sarkar, A., Lehto, S.M., Harty, S., Dinan, T.G., Cryan, J.F. and Burnet, P.W.J., 2016. Psychobiotics and the manipulation of bacteria – gut – brain signals. Trends in Neurosciences 39: 763-781.
'Psychobiotics and the manipulation of bacteria – gut – brain signals ' () 39 Trends in Neurosciences : 763 -781.
-
Saulnier, D.M., Ringel, Y., Heyman, M.B., Foster, J.A., Bercik, P., Shulman, R.J., Versalovic, J., Verdu, E.F., Dinan, T.G., Hecht, G. and Guarner, F., 2013. The intestinal microbiome, probiotics and prebiotics in neurogastroenterology. Gut Microbes 4: 17-27.
'The intestinal microbiome, probiotics and prebiotics in neurogastroenterology ' () 4 Gut Microbes : 17 -27.
-
Whorwell, P.J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O’Mahony, L., Kiely, B., Shanahan, F. and Quigley, E.M., 2006. Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. American Journal of Gastroenterology 101: 1581-1590.
'Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome ' () 101 American Journal of Gastroenterology : 1581 -1590.
-
Yahya, F. and Othman, Z., 2015. Validation of the Malay Version of Hospital Anxiety and Depression Scale (HADS) in Hospital Universiti Sains Malaysia. International Medical Journal 22: 80-82.
'Validation of the Malay Version of Hospital Anxiety and Depression Scale (HADS) in Hospital Universiti Sains Malaysia ' () 22 International Medical Journal : 80 -82.
-
Yusof, N., Hamid, N., Ma, Z.F., Lawenko, R.M., Wan Mohammad, W.M.Z., Collins, D.A., Liong, M.T., Odamaki, T., Xiao, J. and Lee, Y.Y., 2017. Exposure to environmental microbiota explains persistent abdominal pain and irritable bowel syndrome after a major flood. Gut Pathogens 9: 75.
'Exposure to environmental microbiota explains persistent abdominal pain and irritable bowel syndrome after a major flood ' () 9 Gut Pathogens : 75.
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Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster
In: Beneficial MicrobesDepartment of Public Health, Xi’an Jiaotong-Liverpool University, Suzhou 215123, China P.R.
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Individuals in a community who developed irritable bowel syndrome (IBS) after major floods have significant mental health impairment. We aimed to determine if Bifidobacterium infantis M-63 was effective in improving symptoms, psychology and quality of life measures in flood-affected individuals with IBS and if the improvement was mediated by gut microbiota changes. Design was non-randomised, open-label, controlled before-and-after. Of 53 participants, 20 with IBS were given B. infantis M-63 (1×109 cfu/sachet/day) for three months and 33 were controls. IBS symptom severity scale, hospital anxiety and depression scale, SF-36 Questionnaire, hydrogen breath testing for small intestinal bacterial overgrowth and stools for 16S rRNA metagenomic analysis were performed before and after intervention. 11 of 20 who were given probiotics (M-63) and 20 of 33 controls completed study as per-protocol. Mental well-being was improved with M-63 vs controls for full analysis (P=0.03) and per-protocol (P=0.01) populations. Within-group differences were observed for anxiety and bodily pain (both P=0.04) in the M-63 per-protocol population. Lower ratio of Firmicutes/Bacteroidetes was observed with M-63 vs controls (P=0.01) and the lower ratio was correlated with higher post-intervention mental score (P=0.04). B. infantis M-63 is probably effective in improving mental health of victims who developed IBS after floods and this is maybe due to restoration of microbial balance and the gut-brain axis. However, our conclusion must be interpreted within the context of limited sample size. The study was retrospectively registered on 12 October 2017 and the Trial Registration Number (TRN) was NCT03318614.
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