Gout is an acute inflammatory disease characterised by the presence of uric acid crystals in the joint. This event promotes neutrophil infiltration and activation that leads to tissue damage. We investigated here whether the oral administration of the probiotic strain Bifidobacterium longum 51A (BL) could ameliorate monosodium urate crystal (MSU)-induced inflammation in a murine model of gout. Mice received oral administration of BL or saline daily for 7 days and then were injected with MSU in the knee cavity. Treatment with BL significantly alleviated the inflammatory parameters, as seen by reduced hypernociception, reduced neutrophil accumulation in the joint and myeloperoxidase activity in periarticular tissue. There was inhibition of the production of CXCL1 and interleukin(IL)-1β in joints. Levels of the anti-inflammatory cytokine IL-10 were significantly higher in the knee tissue of mice treated with than control mice injected with MSU. In conclusion, oral BL treatment reduced the inflammatory response in an experimental murine model of gout, suggesting it may be useful as an adjuvant treatment in patients with gout.
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Al-Okbi, S.Y., 2011. Role of Bifidobacterium bifidum and plant food extracts in improving microflora and biochemical and cytogenetic parameters in adjuvant arthritis. Grasas y Aceites 62: 12.
'Role of Bifidobacterium bifidum and plant food extracts in improving microflora and biochemical and cytogenetic parameters in adjuvant arthritis ' () 62 Grasas y Aceites : 12.
Amaral, F.A., Costa, V.V., Tavares, L.D., Sachs, D., Coelho, F.M., Fagundes, C.T., Soriani, F.M., Silveira, T.N., Cunha, L.D., Zamboni, D.S., Quesniaux, V., Peres, R.S., Cunha, T.M., Cunha, F.Q., Ryffel, B., Souza, D.G. and Teixeira, M.M., 2012. NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout. Arthritis and Rheumatism 64: 474-484.
'NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout ' () 64 Arthritis and Rheumatism : 474 -484.
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., Van der Veeken, J., deRoos, P., Liu, H., Cross, J.R., Pfeffer, K., Coffer, P.J. and Rudensky, A.Y., 2013. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504: 451-455.
'Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation ' () 504 Nature : 451 -455.
Bardin, T. and Richette, P., 2014. Definition of hyperuricemia and gouty conditions. Current Opinion in Rheumatology 26: 186-191.
'Definition of hyperuricemia and gouty conditions ' () 26 Current Opinion in Rheumatology : 186 -191.
Busso, N. and So, A., 2010. Mechanisms of inflammation in gout. Arthritis Research and Therapy 12: 206.
'Mechanisms of inflammation in gout ' () 12 Arthritis Research and Therapy : 206.
Chen, Y.H., Hsieh, S.C., Chen, W.Y., Li, K.J., Wu, C.H., Wu, P.C., Tsai, C.Y. and Yu, C.L., 2011. Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGFbeta1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3. Annals of the Rheumatic Diseases 70: 1655-1663.
'Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGFbeta1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3 ' () 70 Annals of the Rheumatic Diseases : 1655 -1663.
Coelho, F.M., Pinho, V., Amaral, F.A., Sachs, D., Costa, V.V., Rodrigues, D.H., Vieira, A.T., Silva, T.A., Souza, D.G., Bertini, R., Teixeira, A.L. and Teixeira, M.M., 2008. The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. Arthritis and Rheumatism 58: 2329-2337.
'The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature ' () 58 Arthritis and Rheumatism : 2329 -2337.
Eerola, E., Mottonen, T., Hannonen, P., Luukkainen, R., Kantola, I., Vuori, K., Tuominen, J. and Toivanen, P., 1994. Intestinal flora in early rheumatoid arthritis. British Journal of Rheumatology 33: 1030-1038.
'Intestinal flora in early rheumatoid arthritis ' () 33 British Journal of Rheumatology : 1030 -1038.
Foligne, B., Nutten, S., Grangette, C., Dennin, V., Goudercourt, D., Poiret, S., Dewulf, J., Brassart, D., Mercenier, A. and Pot, B., 2007. Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria. World Journal of Gastroenterology 13: 236-243.
'Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria ' () 13 World Journal of Gastroenterology : 236 -243.
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J.M., Topping, D.L., Suzuki, T., Taylor, T.D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M. and Ohno, H., 2011. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469: 543-547.
'Bifidobacteria can protect from enteropathogenic infection through production of acetate ' () 469 Nature : 543 -547.
Guerra, P.V., Lima, L.N., Souza, T.C., Mazochi, V., Penna, F.J., Silva, A.M., Nicoli, J.R. and Guimaraes, E.V., 2011. Pediatric functional constipation treatment with Bifidobacterium-containing yogurt: a crossover, double-blind, controlled trial. World Journal of Gastroenterology 17: 3916-3921.
'Pediatric functional constipation treatment with Bifidobacterium-containing yogurt: a crossover, double-blind, controlled trial ' () 17 World Journal of Gastroenterology : 3916 -3921.
Hachicha, M., Naccache, P.H. and McColl, S.R., 1995. Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis. Journal of Experimental Medicine 182: 2019-2025.
'Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis ' () 182 Journal of Experimental Medicine : 2019 -2025.
Harrold, L.R., Yood, R.A., Mikuls, T.R., Andrade, S.E., Davis, J., Fuller, J., Chan, K.A., Roblin, D., Raebel, M.A., Von Worley, A., Platt, R. and Saag, K.G., 2006. Sex differences in gout epidemiology: evaluation and treatment. Annals of the Rheumatic Diseases 65: 1368-1372.
'Sex differences in gout epidemiology: evaluation and treatment ' () 65 Annals of the Rheumatic Diseases : 1368 -1372.
Hatakka, K., Martio, J., Korpela, M., Herranen, M., Poussa, T., Laasanen, T., Saxelin, M., Vapaatalo, H., Moilanen, E. and Korpela, R., 2003. Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis – a pilot study. Scandinavian Journal of Rheumatology 32: 211-215.
'Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis – a pilot study ' () 32 Scandinavian Journal of Rheumatology : 211 -215.
Homayouni Rad, A., Torab, R., Ghalibaf, M., Norouzi, S. and Mehrabany, E.V., 2013. Might patients with immune-related diseases benefit from probiotics? Nutrition 29: 583-586.
'Might patients with immune-related diseases benefit from probiotics? ' () 29 Nutrition : 583 -586.
Kobayashi, Y., 2008. The role of chemokines in neutrophil biology. Frontiers in Bioscience 13: 2400-2407.
'The role of chemokines in neutrophil biology ' () 13 Frontiers in Bioscience : 2400 -2407.
Lebeer, S., Vanderleyden, J. and De Keersmaecker, S.C., 2010. Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nature Reviews Microbiology 8: 171-184.
'Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens ' () 8 Nature Reviews Microbiology : 171 -184.
Lee, S.J., Hirsch, J.D., Terkeltaub, R., Khanna, D., Singh, J.A., Sarkin, A. and Kavanaugh, A., 2009. Perceptions of disease and health-related quality of life among patients with gout. Rheumatology 48: 582-586.
'Perceptions of disease and health-related quality of life among patients with gout ' () 48 Rheumatology : 582 -586.
Martin, W.J. and Harper, J.L., 2010. Innate inflammation and resolution in acute gout. Immunology and Cell Biology 88: 15-19.
'Innate inflammation and resolution in acute gout ' () 88 Immunology and Cell Biology : 15 -19.
Martin, W.J., Herst, P.M., Chia, E.W. and Harper, J.L., 2009. Sesquiterpene dialdehydes inhibit MSU crystal-induced superoxide production by infiltrating neutrophils in an in vivo model of gouty inflammation. Free Radical Biology and Medicine 47: 616-621.
'Sesquiterpene dialdehydes inhibit MSU crystal-induced superoxide production by infiltrating neutrophils in an in vivo model of gouty inflammation ' () 47 Free Radical Biology and Medicine : 616 -621.
Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. and Tschopp, J., 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440: 237-241.
'Gout-associated uric acid crystals activate the NALP3 inflammasome ' () 440 Nature : 237 -241.
Maslowski, K.M. and Mackay, C.R., 2011. Diet, gut microbiota and immune responses. Nature Immunology 12: 5-9.
'Diet, gut microbiota and immune responses ' () 12 Nature Immunology : 5 -9.
Maslowski, K.M., Vieira, A.T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H.C., Rolph, M.S., Mackay, F., Artis, D., Xavier, R.J., Teixeira, M.M. and Mackay, C.R., 2009. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461: 1282-1286.
'Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 ' () 461 Nature : 1282 -1286.
Nathan, C., 2006. Neutrophils and immunity: challenges and opportunities. Nature Reviews Immunology 6: 173-182.
'Neutrophils and immunity: challenges and opportunities ' () 6 Nature Reviews Immunology : 173 -182.
Perez, D.A., Vago, J.P., Athayde, R.M., Reis, A.C., Teixeira, M.M., Sousa, L.P. and Pinho, V., 2014. Switching off key signaling survival molecules to switch on the resolution of inflammation. Mediators of Inflammation 2014: 829851.
'Switching off key signaling survival molecules to switch on the resolution of inflammation ' () 2014 Mediators of Inflammation : 829851.
Picard, C., Fioramonti, J., Francois, A., Robinson, T., Neant, F. and Matuchansky, C., 2005. Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits. Alimentary Pharmacology and Therapeutics 22: 495-512.
'Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits ' () 22 Alimentary Pharmacology and Therapeutics : 495 -512.
Pineda Mde, L., Thompson, S.F., Summers, K., de Leon, F., Pope, J. and Reid, G., 2011. A randomized, double-blinded, placebo-controlled pilot study of probiotics in active rheumatoid arthritis. Medical Science Monitor 17: CR347-354.
'A randomized, double-blinded, placebo-controlled pilot study of probiotics in active rheumatoid arthritis ' () 17 Medical Science Monitor : CR347 -354.
Popa-Nita, O. and Naccache, P.H., 2010. Crystal-induced neutrophil activation. Immunology and Cell Biology 88: 32-40.
'Crystal-induced neutrophil activation ' () 88 Immunology and Cell Biology : 32 -40.
Rees, F., Hui, M. and Doherty, M., 2014. Optimizing current treatment of gout. Nature Reviews Rheumatology 10: 271-283.
'Optimizing current treatment of gout ' () 10 Nature Reviews Rheumatology : 271 -283.
Reid, G., Jass, J., Sebulsky, M.T. and McCormick, J.K., 2003. Potential uses of probiotics in clinical practice. Clinical Microbiology Reviews 16: 658-672.
'Potential uses of probiotics in clinical practice ' () 16 Clinical Microbiology Reviews : 658 -672.
Robinson, P.C. and Horsburgh, S., 2014. Gout: joints and beyond, epidemiology, clinical features, treatment and co-morbidities. Maturitas 78: 245-251.
'Gout: joints and beyond, epidemiology, clinical features, treatment and co-morbidities ' () 78 Maturitas : 245 -251.
Roddy, E. and Choi, H.K., 2014. Epidemiology of gout. Rheumatic Diseases Clinics of North America 40: 155-175.
'Epidemiology of gout ' () 40 Rheumatic Diseases Clinics of North America : 155 -175.
Roddy, E. and Doherty, M., 2010. Epidemiology of gout. Arthritis Research and Therapy 12: 223.
'Epidemiology of gout ' () 12 Arthritis Research and Therapy : 223.
Roddy, E., Zhang, W. and Doherty, M., 2007a. The changing epidemiology of gout. Nature Clinical Practice: Rheumatology 3: 443-449.
'The changing epidemiology of gout ' () 3 Nature Clinical Practice: Rheumatology : 443 -449.
Roddy, E., Zhang, W. and Doherty, M., 2007b. Is gout associated with reduced quality of life? A case-control study. Rheumatology 46: 1441-1444.
'Is gout associated with reduced quality of life? A case-control study ' () 46 Rheumatology : 1441 -1444.
Sachs, D., Coelho, F.M., Costa, V.V., Lopes, F., Pinho, V., Amaral, F.A., Silva, T.A., Teixeira, A.L., Souza, D.G. and Teixeira, M.M., 2011. Cooperative role of tumour necrosis factor-alpha, interleukin-1beta and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice. British Journal of Pharmacology 162: 72-83.
'Cooperative role of tumour necrosis factor-alpha, interleukin-1beta and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice ' () 162 British Journal of Pharmacology : 72 -83.
Scher, J.U. and Abramson, S.B., 2011. The microbiome and rheumatoid arthritis. Nature Reviews Rheumatology 7: 569-578.
'The microbiome and rheumatoid arthritis ' () 7 Nature Reviews Rheumatology : 569 -578.
Serhan, C.N., Brain, S.D., Buckley, C.D., Gilroy, D.W., Haslett, C., O’Neill, L.A., Perretti, M., Rossi, A.G. and Wallace, J.L., 2007. Resolution of inflammation: state of the art, definitions and terms. FASEB Journal 21: 325-332.
'Resolution of inflammation: state of the art, definitions and terms ' () 21 FASEB Journal : 325 -332.
Shida, K., Nanno, M. and Nagata, S., 2011. Flexible cytokine production by macrophages and T cells in response to probiotic bacteria: a possible mechanism by which probiotics exert multifunctional immune regulatory activities. Gut Microbes 2: 109-114.
'Flexible cytokine production by macrophages and T cells in response to probiotic bacteria: a possible mechanism by which probiotics exert multifunctional immune regulatory activities ' () 2 Gut Microbes : 109 -114.
Souza, T.C., Silva, A.M., Drews, J.R., Gomes, D.A., Vinderola, C.G. and Nicoli, J.R., 2013. In vitro evaluation of Bifidobacterium strains of human origin for potential use in probiotic functional foods. Beneficial Microbes 4: 179-186.
'In vitro evaluation of Bifidobacterium strains of human origin for potential use in probiotic functional foods ' () 4 Beneficial Microbes : 179 -186.
Souza, T.C., Zacarias, M.F., Silva, A.M., Binetti, A., Reinheimer, J., Nicoli, J.R. and Vinderola, G., 2012. Cell viability and immunostimulating and protective capacities of Bifidobacterium longum 51A are differentially affected by technological variables in fermented milks. Journal of Applied Microbiology 112: 1184-1192.
'Cell viability and immunostimulating and protective capacities of Bifidobacterium longum 51A are differentially affected by technological variables in fermented milks ' () 112 Journal of Applied Microbiology : 1184 -1192.
Terkeltaub, R., 2009. Gout. Novel therapies for treatment of gout and hyperuricemia. Arthritis Research and Therapy 11: 236.
'Gout. Novel therapies for treatment of gout and hyperuricemia ' () 11 Arthritis Research and Therapy : 236.
Terkeltaub, R.A. and Ginsberg, M.H., 1988. The inflammatory reaction to crystals. Rheumatic Diseases Clinics of North America 14: 353-364.
'The inflammatory reaction to crystals ' () 14 Rheumatic Diseases Clinics of North America : 353 -364.
Vaahtovuo, J., Munukka, E., Korkeamaki, M., Luukkainen, R. and Toivanen, P., 2008. Fecal microbiota in early rheumatoid arthritis. Journal of Rheumatology 35: 1500-1505.
'Fecal microbiota in early rheumatoid arthritis ' () 35 Journal of Rheumatology : 1500 -1505.
Vieira, A.T., Macia, L., Galvao, I., Martins, F.S., Cecilia, M., Canesso, C., Amaral, F.A., Garcia, C.C., Maslowski, K.M., De Leon, E., Shim, D., Nicoli, J., Harper, J.L., Teixeira, M.M. and Mackay, C.R., 2015. A role for the gut microbiota and the metabolite sensing receptor GPR43 in a murine model of gout. Arthritis and Rheumatology 67: 1646-1656.
'A role for the gut microbiota and the metabolite sensing receptor GPR43 in a murine model of gout ' () 67 Arthritis and Rheumatology : 1646 -1656.
Vieira, A.T., Teixeira, M.M. and Martins, F.S., 2013. The role of probiotics and prebiotics in inducing gut immunity. Frontiers in Immunology 4: 445.
'The role of probiotics and prebiotics in inducing gut immunity ' () 4 Frontiers in Immunology : 445.
Wu, H.J., Ivanov, II, Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D.R., Benoist, C. and Mathis, D., 2010. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32: 815-827.
'Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells ' () 32 Immunity : 815 -827.
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Gout is an acute inflammatory disease characterised by the presence of uric acid crystals in the joint. This event promotes neutrophil infiltration and activation that leads to tissue damage. We investigated here whether the oral administration of the probiotic strain Bifidobacterium longum 51A (BL) could ameliorate monosodium urate crystal (MSU)-induced inflammation in a murine model of gout. Mice received oral administration of BL or saline daily for 7 days and then were injected with MSU in the knee cavity. Treatment with BL significantly alleviated the inflammatory parameters, as seen by reduced hypernociception, reduced neutrophil accumulation in the joint and myeloperoxidase activity in periarticular tissue. There was inhibition of the production of CXCL1 and interleukin(IL)-1β in joints. Levels of the anti-inflammatory cytokine IL-10 were significantly higher in the knee tissue of mice treated with than control mice injected with MSU. In conclusion, oral BL treatment reduced the inflammatory response in an experimental murine model of gout, suggesting it may be useful as an adjuvant treatment in patients with gout.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 147 | 136 | 10 |
| Full Text Views | 5 | 0 | 0 |
| PDF Views & Downloads | 6 | 1 | 0 |