This study deals with the interaction between neo-Thomism and African traditional thinking in Charles Nyamiti's theological methodology. The approach of the study is groundbreaking as it is the first monograph published on the theological method of any African theologian. The question about the position and relevance of Western philosophical-theological systems in a non-Western context also has a wider relevance concerning contextual theologies in general. Nyamiti's theology is a germane and a fruitful choice for the study of this issue because of his programmatic attempt to build a coherent African Roman Catholic theological system. His theology is also well-known for its strong African flavor in elaborating theological questions within the framework of orthodox Roman Catholic doctrine.